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Registry of Toxic Effects of Chemical Substances (RTECS)

Pyridine, 2-amino-

RTECS #

US1575000

CAS #

504-29-0

Updated

September 201

Molecular Weight

94.13

Molecular Formula

C5H6N2

Synonyms

2-Aminopyridine
2-Aminopyridine (ACGIH:OSHA)
2-Pyridylamine
alpha-Aminopyridine
alpha-Pyridinamine
alpha-Pyridylamine
Amino-2 pyridine

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 5 ppm/5HBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Antipsychotic		IMSUAI 19,317,1950
intracerebral/mouse lethal dose (50 percent kill): 4 mg/kgBehavioral: Convulsions or effect on seizure thresholdAJEBAK 36,365,1958
intraperitoneal/mouse lethal dose (50 percent kill): 25 mg/kgUSXXAM #3816470
intraperitoneal/rat lethal dose (50 percent kill): 48 mg/kgGISAAA 57(9-10),64,1992
intravenous/mouse lethal dose (50 percent kill): 23 mg/kgBehavioral: Convulsions or effect on seizure thresholdAPFRAD 26,345,1968
intravenous/rat lethal dose (50 percent kill): 29 mg/kgAEPPAE 211,367,1950
oral/mouse lethal dose (50 percent kill): 145 mg/kgGISAAA 57(9-10),64,1992
oral/quail lethal dose (50 percent kill): 133 mg/kgAECTCV 12,355,1983
oral/rat lethal dose (50 percent kill): 200 mg/kg85JCAE -,838,1986
oral/wild bird lethal dose (50 percent kill): 31600 µg/kgAECTCV 12,355,1983
skin/guinea pig lethal dose (50 percent kill): 500 mg/kg85JCAE -,838,1986
subcutaneous/mouse lethal dose (50 percent kill): 70 mg/kgAEPPAE 226,163,1955

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 ppm (2 mg/m3)DTLVS* 3,11,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 ppm (2 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.5 ppm (2 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 ppm (1.9 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 ppm (2 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 ppm (2 mg/m3), short term exposure limit 1.5 ppm (5.9 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 0.5 ppm (2 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 ppm (2 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.5 ppm (2 mg/m3), 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 ppm (2 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0.5 ppm (1.9 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 2 mg/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 ppm (2 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 2 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 ppm (2 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.5 ppm (2 mg/m3);short term exposure limit 2 ppm (7,8 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.5 ppm (2 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.5 ppm (2 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.5 ppm (2 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.5 ppm (2 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2-AMINOPYRIDINE-air10H time-weighted average 0.5 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 05215; Number of Industries 3; Total Number of Facilities 61; Number of Occupations 4; Total Number of Employees Exposed 3159; Total Number of Female Employees Exposed 429

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY

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