Registry of Toxic Effects of Chemical Substances (RTECS)
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Silica, amorphous fumed
RTECS #
VV7310000CAS #
112945-52-5; 50926-93-7; 67256-35-3Updated
October 2012Molecular Weight
60.09Molecular Formula
O2SiSynonyms
ActicelAerosil
Amorphous silica dust
Aquafil
Cab-O-grip II
Cab-O-sil
Cab-O-sperse
Cataloid
Colloidal silica
Colloidal silicon dioxide
Davison SG-67
Dicalite
Dri-Die insecticide 67
ENT 25,550
Fossil flour
Fumed silica
Fumed silicon dioxide
Ludox
Nalcoag
Nyacol
Nyacol 1430
Nyacol 830
Pyrogenic colloidal silica
Santocel
SG-67
Silica, amorphous
Silicic anhydride
Silikill
Synthetic amorphous silica, fumed
Vulkasil
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, erythrocytes | Inhibitor Concentration (50 percent kill): 0.29 gm/L/2H | In Vitro Toxicity Studies: Hemolysis in vitro | TIVIEQ 1,239,1987 |
| In Vitro/Mouse, macrophage | Inhibitor Concentration (50 percent kill): 34 mg/L/17H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TIVIEQ 1,77,1987 |
| intraperitoneal/rat | lowest published lethal dose: 50 mg/kg | AHBAAM 136,1,1952 | |
| intratracheal/mouse | lowest published lethal dose: 96.77 mg/kg | Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes | TOPADD 33,745,2005 |
| intratracheal/mouse | lowest published toxic dose: 96.77 mg/kg | Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOPADD 33,745,2005 |
| intratracheal/mouse | lowest published toxic dose: 50 mg/kg | Lung, Thorax, or Respiration: Changes in lung weight | TOLED5 175,24,2007 |
| intratracheal/mouse | lowest published toxic dose: 2 mg/kg | Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOLED5 175,24,2007 |
| intratracheal/mouse | lowest published toxic dose: 2 mg/kg | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases | TOLED5 182,97,2008 |
| intratracheal/mouse | lowest published toxic dose: 50 mg/kg | Lung, Thorax, or Respiration: Fibrosing alveolitis Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOLED5 182,97,2008 |
| intratracheal/rat | lowest published lethal dose: 10 mg/kg | AHBAAM 136,1,1952 | |
| intravenous/rat | lethal dose (50 percent kill): 15 mg/kg | Lung, Thorax, or Respiration: Acute pulmonary edema | BSIBAC 44,1685,1968 |
| oral/rat | lethal dose (50 percent kill): 3160 mg/kg | ARSIM* 20,9,1966 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 154 mg/m3/6H/4W- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Metabolism (intermediary): Other proteins | FAATDF 16,590,1991 |
| inhalation/rat | lowest published toxic concentration: 5.41 mg/m3/5D- intermittent | Lung, Thorax, or Respiration: Other changes Lung, Thorax, or Respiration: Changes in lung weight Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | FCTOD7 45,1856,2007 |
| inhalation/rat | lowest published toxic concentration: 1.39 mg/m3/5D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FCTOD7 45,1856,2007 |
| oral/mouse | lowest published toxic dose: 2500 mg/kg/5D- intermittent | Immunological Including Allergic: Increase in humoral response | TXCYAC 282,82,2011 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 42,39,1987 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 42,39,1987 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 68,41,1997 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMEMDT 68,41,1997 |
| TOXICOLOGY REVIEW | NTIS** CONF-691001 | |
| TOXICOLOGY REVIEW | ECRVE8 6,197,1988 | |
| TOXICOLOGY REVIEW | PTPAD4 120,35,2008 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-dust in air | time-weighted average 20 mppcf | DTLWS* 3,33,1973 |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 2 mg/m3 (respirable dust), JUL2008 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 6 mg/m3 (inhal. dust), OCT2007 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 2.4 mg/m3 (resp. dust), OCT2007 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NIOSH Analytical Method, 1994: Silica, amorphous, 7501 | |
| OSHA ANALYTICAL METHOD #ID-125G |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division