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Registry of Toxic Effects of Chemical Substances (RTECS)

Sodium borate, decahydrate

RTECS #

VZ2275000

CAS #

1303-96-4; 1344-90-7; 12447-40-4; 61028-24-8

Updated

September 201

Molecular Weight

381.42

Molecular Formula

B4O7·2Na·10H2O

Synonyms

Antipyonin
Borascu
Borates, tetra, sodium salt, decahydrate (ACGIH)
Borates, tetra, sodium salts (decahydrate)
Borax (8CI)
Borax decahydrate
Boricin
Disodium tetraborate decahydrate
Gertley borate
Jaikin
Neobor
Sodium biborate decahydrate
Sodium pyroborate decahydrate
Sodium tetraborate decahydrate
Solubor
Three Elephant
Tronabor

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/Drosophila melanogaster714 ppmSOGEBZ 10,601,1974
specific locus testoral/Drosophila melanogaster714 ppmSOGEBZ 10,601,1974

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 70 gm/kg (90D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductTXAPA9 23,351,1972
oral/rat 70 gm/kg (90D prior to copulation)Reproductive: Maternal effects: Ovaries, fallopian tubesTXAPA9 23,351,1972
oral/rat 37 gm/kg (multigenerations)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)TXAPA9 23,351,1972
oral/Dog 70 gm/kg (26W male)Reproductive: Paternal effects: Testes, epididymis, sperm ductTXAPA9 23,351,1972

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 48 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
intraperitoneal/mouse lethal dose (50 percent kill): 2711 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle contraction or spasticity		AIPTAK 143,144,1963
intravenous/mouse lethal dose (50 percent kill): 1320 mg/kg14KTAK -,693,1964
oral/Dog lowest published lethal dose: 3 gm/kgHBAMAK 4,1289,1935
oral/guinea pig lethal dose (50 percent kill): 5330 mg/kg14KTAK -,693,1964
oral/infant lowest published lethal dose: 1 gm/kgPCOC** -,144,1966
oral/man lowest published lethal dose: 709 mg/kgBehavioral: Convulsions or effect on seizure threshold

Cardiac: Change in rate

Gastrointestinal: Nausea or vomiting		JAMAAP 76,378,1921
oral/mouse lethal dose (50 percent kill): 2 gm/kg14KTAK -,693,1964
oral/rat lethal dose (50 percent kill): 2660 mg/kgFMCHA2 -,C48,1991
subcutaneous/rabbit lowest published lethal dose: 150 mg/kgHBAMAK 4,1289,1935

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 35 gm/kg/90D- continuousLiver: Changes in liver weight

Endocrine: Changes in thyroid weight

Related to Chronic Data: Changes in testicular weight		TXAPA9 23,351,1972
oral/rat lowest published toxic dose: 70 gm/kg/90D- continuousBrain and Coverings: Changes in brain weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight		TXAPA9 23,351,1972
oral/rat lowest published toxic dose: 377 gm/kg/2Y- continuousBlood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight		TXAPA9 23,351,1972
oral/rat lowest published toxic dose: 18524 mg/kg/70D- continuousEndocrine: Changes in spleen weight

Blood: Other changes

Related to Chronic Data: Changes in testicular weight		BECTA6 25,782,1980

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 mg/m3;short term exposure limit 6 mg/m3 (inhal)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWREPTED 29,10,2010

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,90,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 2 mg/m3, short term exposure limit 6 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 2 mg/m3, skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 mg(B)/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 5 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 2 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 5 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 ppm, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.2 mg/m2, MAC(short term exposure limit) 2 mg/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 2 mg/m3;short term exposure limit 5 mg/m3, Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 5 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 mg/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BORATES, decahydrate-air10H time-weighted average 5 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code T1956; Number of Industries 196; Total Number of Facilities 29342; Number of Occupations 132; Total Number of Employees Exposed 442072; Total Number of Female Employees Exposed 88646
National Occupational Exposure Survey 1983Hazard Code X6986; Number of Industries 3; Total Number of Facilities 143; Number of Occupations 4; Total Number of Employees Exposed 1615; Total Number of Female Employees Exposed 53

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

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