Registry of Toxic Effects of Chemical Substances (RTECS)
ShareCompartir
Succinic acid, mercapto-, diethyl ester, S-ester with O,O-dimethylphosphorodithioate
RTECS #
WM8400000CAS #
121-75-5Updated
December 2013Molecular Weight
330.38Molecular Formula
C10H19O6PS2Synonyms
((Dimethoxyphosphinothioyl)thio)butanedioic acid diethyl ester1,2-Di(ethoxycarbonyl)ethyl O,O-dimethyl phosphorodithioate
American cyanamid 4,049
Carbethoxy malathion
Carbetovur
Carbetox
Carbofos
Carbophos
Chemathion
Cimexan
Compound 4049
Cythion
Detmol MA
Detmol MA 96%
Dicarboethoxyethyl O,O-dimethyl phosphorodithioate
Diethyl ((dimethoxyphosphinothioyl)thio)butanedioate
Diethyl (dimethoxyphosphinothioylthio)succinate
Diethyl mercaptosuccinate S-ester with O,O-dimethylphosphorodithioate
Diethyl mercaptosuccinate, O,O-dimethyl dithiophosphate, S-ester
Diethyl mercaptosuccinate, O,O-dimethyl phosphorodithioate
Diethyl mercaptosuccinate, O,O-dimethyl thiophosphate
Diethyl mercaptosuccinic acid O,O-dimethyl phosphorodithioate
Dithiophosphate de O,O-dimethyle et de S-(1,2-dicarboethoxyethyle) (French)
EL 4049
Emmatos
Emmatos Extra
ENT 17,034
Ethiolacar
Etiol
Experimental insecticide 4049
Extermathion
Forthion
Fosfothion
Fosfotion
Fosfotion 550
Fyfanon
Hilthion
Hilthion 25WDP
Insecticide No. 4049
Karbofos
Kop-thion
Kypfos
Latka 4049 (Czech)
Malacide
Malafor
Malagran
Malakill
Malamar
Malamar 50
Malaphele
Malaphos
Malasol
Malaspray
Malathion
Malathion (ACGIH:OSHA)
Malathion E50
Malathion LV concentrate
Malathion ULV concentrate
Malathon
Malathyl LV concentrate & ULV concentrate
Malation (Polish)
Malatol
Malatox
Maldison
Malmed
Malphos
Maltox
Maltox MLT
Mercaptosuccinic acid diethyl ester
Mercaptothion
Mercaptotion (Spanish)
Moscarda
NCI-C00215
O,O-Dimethyl S-(1,2-bis(ethoxycarbonyl)ethyl)dithiophosphate
O,O-Dimethyl S-(1,2-dicarbethoxyethyl) dithiophosphate
O,O-Dimethyl S-(1,2-dicarbethoxyethyl) thiothionophosphate
O,O-Dimethyl S-(1,2-dicarbethoxyethyl)phosphorodithioate
O,O-Dimethyl S-1,2-di(ethoxycarbamyl)ethyl phosphorodithioate
O,O-Dimethyldithiophosphate diethylmercaptosuccinate
O,O-Dimethyl-S-1,2-(dicarbaethoxyaethyl)-dithiophosphat (German)
O,O-Dimethyl-S-1,2-dikarbetoxylethylditiofosfat (Czech)
O,O-Dwumetylo-S-1,2-bis(karboetoksyetylo)-dwutiofosforan (Polish)
Oleophosphothion
Ortho malathion
Phosphorodithioic acid, O,O-dimethyl ester, S-ester with diethyl mercaptosuccinate
Phosphothion
Prentox malathion 95% spray
Prioderm
S-(1,2-Bis(aethoxy-carbonyl)-aethyl)-O,O-dimethyl-dithiophosphat (German)
S-(1,2-Bis(carbethoxy)ethyl) O,O-dimethyl dithiophosphate
S-(1,2-Bis(ethoxycarbonyl)ethyl) O,O-dimethyl phosphorodithioate
S-(1,2-Bis(ethoxy-carbonyl)-ethyl)-O,O-dimethyl-dithiofosfaat (Dutch)
S-(1,2-Bis(etossi-carbonil)-etil)-O,O-dimetil-ditiofosfato (Italian)
S-(1,2-Di(ethoxycarbonyl)ethyl) dimethyl phosphorothiolothionate
S-(1,2-Dicarbethoxyethyl) O,O-dimethyldithiophosphate
S-1,2-Bis(ethoxycarbonyl)ethyl-O,O-dimethyl thiophosphate
Sadofos
Sadophos
SF 60
Siptox I
Sumitox
TAK
TM-4049
Vegfru malatox
Vetiol
Zithiol
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | multiple/other fish | 200 nL/L | JFIBA9 26,13,1985 |
| Cytogenetic Analysis | lymphocyte/human | 50 mg/L | CYTOAN 54,191,1989 |
| Cytogenetic Analysis | leukocyte/human | 2 mg/L | MUREAV 301,13,1993 |
| Cytogenetic Analysis | oral/mouse | 14 mg/kg/7D-continuous | FCTOD7 33,309,1995 |
| Cytogenetic Analysis | skin/mouse | 500 mg/kg | MUREAV 204,283,1988 |
| Cytogenetic Analysis | intraperitoneal/hamster | 240 mg/kg | ARTODN 58,152,1986 |
| Cytogenetic Analysis | lung/hamster | 76 mg/L | GMCRDC 27,95,1981 |
| Cytogenetic Analysis | ovary/hamster | 303 mg/L | EMMUEG 10(Suppl 10),1,1987 |
| Cytogenetic Analysis | lymphocyte/mammal (species unspecified) | 25 mg/L | CUSCAM 57,280,1988 |
| Cytogenetic Analysis | oral/mouse | 121 mg/kg/12W | MUREAV 513,1,2002 |
| Cytogenetic Analysis | intraperitoneal/mouse | 5 mg/kg | MUREAV 514,223,2002 |
| Cytogenetic Analysis | oral/mouse | 5 mg/kg | MUREAV 514,223,2002 |
| Cytogenetic Analysis | oral/mouse | 10 mg/kg/5D | MUREAV 514,223,2002 |
| Cytogenetic Analysis | intraperitoneal/rat | 25 mg/kg/5D- intermittent | MUREAV 725,78,2011 |
| DNA Damage | intraperitoneal/rat | 12.5 mg/kg/5D- intermittent | MUREAV 725,78,2011 |
| DNA Damage | intraperitoneal/rat | 199.9 mg/kg | TXCYAC 253,8,2008 |
| DNA Damage | /Escherichia coli | 100 mg/L | MUREAV 52,161,1978 |
| DNA inhibition | lymphocyte/human | 70 mg/L | HUGEDQ 53,375,1980 |
| Dominant Lethal Test | oral/Drosophila melanogaster | 2500 ng/L | FCTOD7 33,309,1995 |
| micronucleus test | lymphocyte/human | 75 mg/L | MUREAV 388,85,1997 |
| mutation in microorganisms | /Salmonella typhimurium | 10 mg/L (+enzymatic activation step) | CYGEDX 15(3),64,1981 |
| mutation in microorganisms | /Bacillus subtilis | 1 nmol/plate (-enzymatic activation step) | MSERDS 5,93,1981 |
| mutation in microorganisms | /Other microorganisms | 100 mg/L (-enzymatic activation step) | CYGEDX 15(3),64,1981 |
| other mutation test systems | lymphocyte/human | 70 mg/L | ENVRAL 41,372,1986 |
| other mutation test systems | leukocyte/human | 20 µg/L | MUREAV 301,13,1993 |
| other mutation test systems | lymphocyte/human | 10 mg/L | HUGEDQ 56,189,1980 |
| other mutation test systems | skin/mouse | 1 gm/kg | MUREAV 204,283,1988 |
| other mutation test systems | lymphocyte/mammal (species unspecified) | 50 mg/L | CUSCAM 57,280,1988 |
| sister chromatid exchange | oral/mouse | 10 mg/kg/5D | MUREAV 514,223,2002 |
| sister chromatid exchange | oral/mouse | 121 mg/kg/12W | MUREAV 513,1,2002 |
| sister chromatid exchange | intraperitoneal/mouse | 5 mg/kg | MUREAV 514,223,2002 |
| sister chromatid exchange | ovary/hamster | 300 µmol/L | JTEHD6 8,939,1981 |
| sister chromatid exchange | lung/hamster | 40 mg/L | MUREAV 88,307,1981 |
| sister chromatid exchange | lymphocyte/human | 20 mg/L | CYTOAN 54,191,1989 |
| sister chromatid exchange | fibroblast/human | 5 mg/L | MUREAV 67,167,1979 |
| sister chromatid exchange | leukocyte/human | 20 mg/L | MUREAV 301,13,1993 |
| specific locus test | oral/Drosophila melanogaster | 4 µg/L | FCTOD7 33,309,1995 |
| sperm morphology | intraperitoneal/mouse | 5 mg/kg | MUREAV 514,223,2002 |
| sperm morphology | sperm/human | 50 µmol/L/1H | REPTED 22,508,2006 |
| Unscheduled DNA Synthesis | lymphocyte/human | 10 mg/L | HUGEDQ 56,189,1980 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 5550 mg/kg (91D prior to copulation/1-20D pregnant) | Reproductive: Specific developmental abnormalities: Body wall | JTEHD6 14,267,1984 |
| oral/rat | 43920 mg/kg (multigenerations) | Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Other postnatal measures or effects | NATUAS 192,464,1961 |
| oral/rat | 191 mg/kg (9D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | JFMAAQ 54,452,1967 |
| oral/rat | 283 mg/kg (9D pregnant) | Reproductive: Specific developmental abnormalities: Urogenital system | JFMAAQ 54,452,1967 |
| oral/rabbit | 540 mg/kg (28-30D pregnant) | Reproductive: Other effects to embryo or fetus | MSCREJ 17,743,1989 |
| oral/rat | 20 mg/kg (11-17D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | FATOAO 52,87,1989 |
| oral/rat | 40 mg/kg (11-17D pregnant) | Reproductive: Effects on newborn: Other postnatal measures or effects | FATOAO 52,87,1989 |
| subcutaneous/mouse | 420 mg/kg (1-21D after birth) | Reproductive: Effects on newborn: Biochemical and metabolic | NRTXDN 27,1101,2006 |
| unreported route/rat | 40 mg/kg (11-17D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Delayed effects | FATOAO 54,80,1991 |
| unreported route/rat | 80 mg/kg (2D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | BECTA6 15,458,1976 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Chicken, neurons | Inhibitor Concentration (50 percent kill): 5423 µmol/L/21H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 7,653,1993 |
| In Vitro/Chicken, neurons | Inhibitor Concentration (10 percent kill): 1927 µmol/L/21H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 7,653,1993 |
| In Vitro/Chicken, neurons | Inhibitor Concentration (50 percent kill): 3448 µmol/L/20H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 7,653,1993 |
| In Vitro/Chicken, neurons | Inhibitor Concentration (10 percent kill): 1851 µmol/L/20H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 7,653,1993 |
| In Vitro/Human, liver | Inhibitor Concentration (10 percent kill): 0.62 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 8,47,1994 |
| In Vitro/Human, liver | Inhibitor Concentration (50 percent kill): 1.58 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 8,47,1994 |
| In Vitro/Human, liver tumor | Inhibitor Concentration (10 percent kill): 0.8 mmol/L/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 8,47,1994 |
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 2.59 mmol/L/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 8,47,1994 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration (50 percent kill): 1.3 mmol/L/60M | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 245,191,2010 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (10 percent kill): 0.27 mmol/L/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 8,47,1994 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (50 percent kill): 1.09 mmol/L/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 8,47,1994 |
| In Vitro/pha | Inhibitor Concentration Low: 10 µmol/L/2H | In Vitro Toxicity Studies: Cell protein synthesis | NETEEC 32,58,2011 |
| In Vitro/Rat, liver | Inhibitor Concentration (10 percent kill): 0.33 mmol/L/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 8,47,1994 |
| In Vitro/Rat, liver | Inhibitor Concentration (50 percent kill): 1.02 mmol/L/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 8,47,1994 |
| In Vitro/Rat, lung | Inhibitor Concentration (50 percent kill): 0.16 gm/L/24H | In Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM) | TIVIEQ 7,111,1993 |
| In Vitro/Rat, lung | Inhibitor Concentration (50 percent kill): 0.42 gm/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 7,111,1993 |
| In Vitro/Rat, lung | Inhibitor Concentration (10 percent kill): 0.05 gm/L/24H | In Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM) | TIVIEQ 7,111,1993 |
| In Vitro/Rat, lung | Inhibitor Concentration (75 percent kill): 0.34 gm/L/24H | In Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM) | TIVIEQ 7,111,1993 |
| In Vitro/Rat, lung | Inhibitor Concentration (10 percent kill): 0.07 gm/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 7,111,1993 |
| In Vitro/Rat, lung | Inhibitor Concentration (75 percent kill): 1.3 gm/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 7,111,1993 |
| inhalation/cat | Lowest published lethal concentration: 10 mg/m3/4H | 85GMAT -,56,1982 | |
| inhalation/rat | lethal concentration (50 percent kill): 43790 µg/m3/4H | GISAAA 56(2),80,1991 | |
| intraarterial/cat | lowest published lethal dose: 1820 µg/kg | 14KTAK -,693,1964 | |
| intraperitoneal/Dog | lethal dose (50 percent kill): 1857 mg/kg | TXAPA9 15,244,1969 | |
| intraperitoneal/guinea pig | lethal dose (50 percent kill): 271 mg/kg | AEPPAE 236,202,1959 | |
| intraperitoneal/hamster | lethal dose (50 percent kill): 2400 mg/kg | ARTODN 58,152,1986 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 193 mg/kg | PSEBAA 129,699,1968 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 250 mg/kg | ARZNAD 22,1926,1972 | |
| intraperitoneal/rat | lowest published toxic dose: 250 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | TOLED5 187,137,2009 |
| intravenous/man | lowest published toxic dose: 14 µL/kg | Vascular: Other changes Skin: After systemic exposure: Dermatitis, other | JJAMA* 16,367,1992 |
| intravenous/mouse | lethal dose (50 percent kill): 184 mg/kg | BLLIAX 38,151,1958 | |
| intravenous/rat | lethal dose (50 percent kill): 50 mg/kg | ARZNAD 5,626,1955 | |
| oral/cattle | lethal dose (50 percent kill): 53 mg/kg | Peripheral Nerve and Sensation: Fasciculations Behavioral: Convulsions or effect on seizure threshold Behavioral: Rigidity (includes catalepsy) | IVEJAC 56,650,1979 |
| oral/chicken | lethal dose (50 percent kill): 600 mg/kg | Behavioral: Food intake (animal) | IJEBA6 9,455,1971 |
| oral/chicken | lethal dose (50 percent kill): 1000 mg/kg | HBPTO* 2,957,2001 | |
| oral/domestic animal | lethal dose (50 percent kill): 500 mg/kg | 85DPAN -,-,1971/1976 | |
| oral/duck | lethal dose (50 percent kill): 1485 µg/kg | DOEAAH 35,25,1979 | |
| oral/guinea pig | lethal dose (50 percent kill): 570 mg/kg | ARZNAD 5,626,1955 | |
| oral/man | lowest published lethal dose: 471 mg/kg | Behavioral: Coma Vascular: BP lowering not characterized in autonomic section Lung, Thorax, or Respiration: Dyspnea | ATXKA8 23,11,1967 |
| oral/mouse | lethal dose (50 percent kill): 190 mg/kg | 85GMAT -,56,1982 | |
| oral/rabbit | lowest published lethal dose: 1200 mg/kg | Lung, Thorax, or Respiration: Respiratory stimulation | AEHA** 99-002-74/1976 |
| oral/rat | lethal dose (50 percent kill): 644 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | FATOAO 53,64,1990 |
| oral/rat | lethal dose (50 percent kill): 290 mg/kg | 85GMAT -,56,1982 | |
| oral/rat | lowest published toxic dose: 100 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOSCF2 92,235,2006 |
| oral/rat | lowest published toxic dose: 500 mg/kg | Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOSCF2 92,235,2006 |
| oral/rat | lowest published toxic dose: 400 mg/kg | Gastrointestinal: Changes in structure or function of exocrine pancreas Liver: Other changes Endocrine: Hyperglycemia | FCLPH* 22(Suppl 1),36,2008 |
| oral/rat | lowest published toxic dose: 100 mg/kg | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | TXCYAC 250,27,2008 |
| oral/rat | lethal dose (50 percent kill): 450 mg/kg | Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Respiratory stimulation Endocrine: Hyperglycemia | TPKVAL 7,122,1965 |
| oral/rat | lowest published toxic dose: 360 mg/kg | Lung, Thorax, or Respiration: Respiratory depression Blood: Hemorrhage Blood: Methemoglobinemia- Carboxhemoglobinemia | TPKVAL 7,122,1965 |
| oral/wild bird | lethal dose (50 percent kill): 400 mg/kg | AECTCV 12,355,1983 | |
| oral/woman | lowest published lethal dose: 246 mg/kg | Vascular: BP lowering not characterized in autonomic section Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Skin: After systemic exposure: Dermatitis, other | AEHLAU 33,240,1978 |
| oral/woman | lowest published toxic dose: 300 µL/kg | Behavioral: Coma Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Cyanosis | HETOEA 13,271,1994 |
| oral/woman | lowest published lethal dose: 8 mL/kg | Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Other changes Gastrointestinal: Other changes | FSINDR 95,89,1998 |
| oral/woman | lowest published toxic dose: 200 µL/kg | Behavioral: Coma Gastrointestinal: Changes in structure or function of exocrine pancreas Lung, Thorax, or Respiration: Respiratory depression | IJMDAI 30,855,1994 |
| skin/guinea pig | lethal dose (50 percent kill): 6700 mg/kg | AMCYC* 8/1966 | |
| skin/mouse | lethal dose (50 percent kill): 2330 mg/kg | ABCHA6 27,684,1963 | |
| skin/rabbit | lethal dose (50 percent kill): 4100 mg/kg | 28ZEAL 5,142,1976 | |
| skin/rat | lethal dose (50 percent kill): >4444 mg/kg | PMJMAQ -,155,1957 | |
| subcutaneous/guinea pig | lethal dose (50 percent kill): 450 mg/kg | Eye: Lacrimation Behavioral: Muscle contraction or spasticity Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TPKVAL 7,122,1965 |
| subcutaneous/guinea pig | lethal dose (50 percent kill): 450 mg/kg | Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Respiratory stimulation Endocrine: Hyperglycemia | TPKVAL 7,122,1965 |
| subcutaneous/guinea pig | lowest published toxic dose: 112.5 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Other proteins | TPKVAL 7,122,1965 |
| subcutaneous/mouse | lowest published toxic dose: 1000 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NRTXDN 29,184,2008 |
| subcutaneous/mouse | lethal dose (50 percent kill): 221 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase | OIZAAV 71,6099,1959 |
| subcutaneous/rabbit | lethal dose (50 percent kill): 280 mg/kg | Kidney, Ureter, and Bladder: Urine volume increased Endocrine: Hyperglycemia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TPKVAL 7,122,1965 |
| subcutaneous/rabbit | lethal dose (50 percent kill): 280 mg/kg | Eye: Lacrimation Behavioral: Muscle contraction or spasticity Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TPKVAL 7,122,1965 |
| subcutaneous/rat | lethal dose (50 percent kill): 400 mg/kg | Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Respiratory stimulation Endocrine: Hyperglycemia | TPKVAL 7,122,1965 |
| subcutaneous/rat | lethal dose (50 percent kill): 400 mg/kg | Eye: Lacrimation Behavioral: Muscle contraction or spasticity Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TPKVAL 7,122,1965 |
| unreported route/cattle | lethal dose (50 percent kill): 53 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement Behavioral: Change in motor activity (specific assay) | IJLAA4 49,314,1979 |
| unreported route/mammal (species unspecified) | lethal dose (50 percent kill): 500 mg/kg | 30ZDA9 -,357,1971 | |
| unreported route/mammal (species unspecified) | lowest published toxic dose: 715 mg/kg | Immunological Including Allergic: Decrease in cellular immune response Blood: Changes in cell count (unspecified) | HBPTO* 1,773,2001 |
| unreported route/mammal (species unspecified) | lowest published toxic dose: 0.25 mg/kg | Immunological Including Allergic: Decrease in cellular immune response | HBPTO* 1,773,2001 |
| unreported route/mouse | lethal dose (50 percent kill): 375 mg/kg | GISAAA 50(3),4,1985 | |
| unreported route/rat | lethal dose (50 percent kill): 124 mg/kg | HBPTO* 1,786,2001 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 2300 µg/m3/4H/13W- intermittent | Endocrine: Other changes Blood: Changes in other cell count (unspecified) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | GISAAA 41(8),93,1976 |
| intraperitoneal/rat | lowest published toxic dose: 1050 mg/kg/7D- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Somnolence (general depressed activity) Biochemical: Metabolism (intermediary): Lipids including transport | PHTOEH 61,12,1987 |
| intraperitoneal/rat | lowest published toxic dose: 150 mg/kg/3D- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | TOSCF2 97,140,2007 |
| intraperitoneal/rat | lowest published toxic dose: 4725 mg/kg/5W- intermittent | Lung, Thorax, or Respiration: Fibrosis (interstitial) Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Blood: Changes in leukocyte (WBC) count | RJENT* 2,85,2008 |
| intraperitoneal/rat | lowest published toxic dose: 300 mg/kg/3D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | BCLPT* 102,365,2008 |
| multiple/non-mammalian species | : 500 mg/m3/7D- continuous | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases | TXCYAC 212,107,2005 |
| oral/Dog | lowest published toxic dose: 210 mg/kg/12W- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | FCTXAV 6,185,1968 |
| oral/Dog | lowest published toxic dose: 175 mg/kg/4W- continuous | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | JPETAB 121,96,1957 |
| oral/domestic animal | lowest published toxic dose: 150 mg/kg/6D- intermittent | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Blood: Hemorrhage Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VHTODE 41,287,1999 |
| oral/human | lowest published toxic dose: 19.04 mg/kg/56D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 1,59,2001 |
| oral/mouse | lowest published toxic dose: 504 mg/kg/12W- continuous | Endocrine: Changes in spleen weight Immunological Including Allergic: Decrease in cellular immune response Immunological Including Allergic: Decrease in humoral immune response | IJEBA6 36,273,1998 |
| oral/mouse | lowest published toxic dose: 1500 mg/kg/15D- intermittent | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | BECTA6 63,575,1999 |
| oral/rabbit | lowest published toxic dose: 368 mg/kg/21W- intermittent | Immunological Including Allergic: Decrease in cellular immune response Immunological Including Allergic: Decrease in humoral immune response | IJEBA6 36,273,1998 |
| oral/rat | lowest published toxic dose: 288 mg/kg/90D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 1,59,2001 |
| oral/rat | lowest published toxic dose: 3285 mg/kg/730D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 1,59,2001 |
| oral/rat | lowest published toxic dose: 900 mg/kg/90D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JDGRAX 18,145,1989 |
| oral/rat | lowest published toxic dose: 462 mg/kg/22W- continuous | Endocrine: Changes in spleen weight Immunological Including Allergic: Decrease in cellular immune response Immunological Including Allergic: Decrease in humoral immune response | IJEBA6 36,273,1998 |
| oral/rat | lowest published toxic dose: 2250 mg/kg/45D- intermittent | Gastrointestinal: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Metabolism (intermediary): Amino acids (including renal excretion) | BECTA6 33,289,1984 |
| oral/rat | lowest published toxic dose: 1050 mg/kg/21D- intermittent | Liver: Other changes Biochemical: Metabolism (intermediary): Amino acids (including renal excretion) | AECTCV 14,459,1985 |
| oral/rat | lowest published toxic dose: 3358 mg/kg/14D- continuous | Behavioral: Fluid intake Blood: Change in clotting factors | JEPOEC 6(1),51,1985 |
| oral/rat | lowest published toxic dose: 3200 mg/kg/32D- intermittent | Behavioral: Food intake (animal) Liver: Other changes Liver: Changes in liver weight | TXCYAC 223,9,2006 |
| oral/rat | lowest published toxic dose: 140 mg/kg/2W- intermittent | Endocrine: Change in gonadotropins Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | BECTA6 18,231,1977 |
| oral/rat | lowest published toxic dose: 168 mg/kg/4W- continuous | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Metabolism (intermediary): Lipids including transport | CBCPAI 137,29,2004 |
| oral/rat | lowest published toxic dose: 168 mg/kg/4W- continuous | Liver: Other changes Endocrine: Hyperglycemia Biochemical: Metabolism (intermediary): Glycolytic | CBCPAI 137,343,2004 |
| oral/rat | lowest published toxic dose: 4200 mg/kg/28D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | ARTODN 82,543,2008 |
| oral/rat | lowest published toxic dose: 756 mg/kg/4W- intermittent | Liver: Hepatitis (hepatocellular necrosis), diffuse Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Lipids including transport | FCTOD7 48,633,2010 |
| oral/rat | lowest published toxic dose: 756 mg/kg/4W- intermittent | Endocrine: Change in gonadotropins Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | FCTOD7 47,1903,2009 |
| oral/rat | lowest published toxic dose: 3200 mg/kg/32D- intermittent | Liver: Multiple effects Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | FCLPH* 21(Suppl 1),98,2007 |
| oral/rat | lowest published toxic dose: 3200 mg/kg/32D- intermittent | Brain and Coverings: Other degenerative changes Endocrine: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | FCTOD7 48,1473,2010 |
| skin/rat | lowest published toxic dose: 1332 mg/kg/30D- intermittent | Brain and Coverings: Other degenerative changes | TOXID9 78,86,2004 |
| skin/rat | lowest published toxic dose: 1332 mg/kg/30D- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Change in motor activity (specific assay) | JTEHF8 67,331,2004 |
| subcutaneous/guinea pig | lowest published toxic dose: 18900 mg/kg/24W- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 7,122,1965 |
| subcutaneous/guinea pig | lowest published toxic dose: 1125 mg/kg/10D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 7,122,1965 |
| subcutaneous/mouse | lowest published toxic dose: 4200 mg/kg/21D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NRTXDN 27,1101,2006 |
| subcutaneous/rabbit | lowest published toxic dose: 11760 mg/kg/24W- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 7,122,1965 |
| subcutaneous/rabbit | lowest published toxic dose: 2100 mg/kg/30D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 7,122,1965 |
| subcutaneous/rat | lowest published toxic dose: 1000 mg/kg/10D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TPKVAL 7,122,1965 |
| subcutaneous/rat | lowest published toxic dose: 16800 mg/kg/24W- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 7,122,1965 |
| unreported route/rabbit | lowest published toxic dose: 1750 mg/kg/5W- intermittent | Immunological Including Allergic: Decrease in humoral immune response | HBPTO* 1,773,2001 |
| unreported route/rat | lowest published toxic dose: 5.6 gm/kg/14D- intermittent | Brain and Coverings: Other degenerative changes Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 2,1035,2001 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 1 mg/m3 (inhal, vapor, skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 30,103,1983 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 30,103,1983 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMSUDL 7,56,1987 |
| TOXICOLOGY REVIEW | AQMOAC #73-19,1973 | |
| TOXICOLOGY REVIEW | RREVAH 46,1,1973 | |
| TOXICOLOGY REVIEW | CNDQA8 10(3),43,1975 | |
| TOXICOLOGY REVIEW | PMDCAY 10,85,1974 | |
| TOXICOLOGY REVIEW | DTTIAF 80,485,1973 | |
| TOXICOLOGY REVIEW | RREVAH 63,1,1976 | |
| TOXICOLOGY REVIEW | JTCTDW 38,47,2000 | |
| TOXICOLOGY REVIEW | MUREAV 562,77,2004 | |
| TOXICOLOGY REVIEW | MUTAEX 21,93,2006 | |
| TOXICOLOGY REVIEW | NETOX* 26,531,2005 | |
| TOXICOLOGY REVIEW | NRTXDN 27,628,2006 | |
| TOXICOLOGY REVIEW | MUTAEX 20,389,2005 | |
| TOXICOLOGY REVIEW | CCATAR 366,1,2006 | |
| TOXICOLOGY REVIEW | ENTOX* -,588,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,306,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,308,2005 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | REPTED 23,260,2007 | |
| TOXICOLOGY REVIEW | JTPAE7 19,1,2006 | |
| TOXICOLOGY REVIEW | ITODC* -,355,2004 | |
| TOXICOLOGY REVIEW | MUREAV 543,251,2003 | |
| TOXICOLOGY REVIEW | HTOPA* 1,501,2002 | |
| TOXICOLOGY REVIEW | MUREAV 674,137,2009 | |
| TOXICOLOGY REVIEW | FEREAC 74,22478,2009 | |
| TOXICOLOGY REVIEW | HETOEA 26,321,2007 | |
| TOXICOLOGY REVIEW | FCTOD7 47,2906,2009 | |
| TOXICOLOGY REVIEW | FEREAC 74,47451,2009 | |
| TOXICOLOGY REVIEW | MUTAEX 23,271,2008 | |
| TOXICOLOGY REVIEW | NBREV* 9,479,1985 | |
| TOXICOLOGY REVIEW | MUTAEX 26,19,2011 | |
| TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
| TOXICOLOGY REVIEW | NRTXDN 33,575,2012 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Supported | RBREV* -,128,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 10 mg/m3 (skin) | DTLVS* 3,148,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 10 mg/m3, Skin, JAN1993 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 10 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 10 mg/m3, inhal, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 1 mg/m3 (vapor, aerosol), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 5 mg/m3, skin, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 10 mg/m3, Skin, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 15 mg/m3, inhal, 2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 10 mg/m3, skin, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 10 mg/m3, skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 10 mg/m3 (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 mg/m3, skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 5 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 1 mg/m3, JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 10 mg/m3, inhal, skin, JAN2011 | |
| Occupational Exposure Limit-THAILAND | time-weighted average 15 mg/m3, JAN1993 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 10 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 15 mg/m3, Skin, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 15 mg/m3, Skin, JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 10 mg/m3, skin, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 15 mg/m3 (skin), total dust | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 15 mg/m3 (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 15 mg/m3 (skin), total dust | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 15 mg/m3 (skin), total dust | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MALATHION-air | 10H time-weighted average 10 mg/m3 (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 80046; Number of Industries 15; Total Number of Facilities 2146; Number of Occupations 18; Total Number of Employees Exposed 19170; Total Number of Female Employees Exposed 1909 | |
| National Occupational Hazard Survey 1974 | Hazard Code 80046; Number of Industries 13; Total Number of Facilities 1609; Number of Occupations 14; Total Number of Employees Exposed 17242 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| ATSDR TOXICOLOGY PROFILE (NTIS** PB2004/100003) | |
| EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9 | |
| EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Histidine reversion-Ames test | |
| EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal | |
| EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion | |
| EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis | |
| EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-human | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Bioassay (feed);no evidence:rat | NCITR* NCI-TR-192,1979 |
| NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600 | |
| On EPA IRIS database | |
| OSHA ANALYTICAL METHOD #ID-62 |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division