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Registry of Toxic Effects of Chemical Substances (RTECS)

Toluenediamine

RTECS #

XS9445000

CAS #

25376-45-8; 26764-44-3; 30143-13-6

Updated

July 2010

Molecular Weight

122.19

Molecular Formula

C7H10N2

Synonyms

Benzenediamine, ar-methyl-
Diaminotoluene
Methylphenylenediamine
RCRA waste number U221
TDA 8020
Tolylenediamine

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 240 mg/kgZHYGAM 29,395,1983
intraperitoneal/rat lethal dose (50 percent kill): 230 mg/kgZHYGAM 29,395,1983
intravenous/mouse lethal dose (50 percent kill): 90 mg/kgZHYGAM 29,395,1983
intravenous/rat lethal dose (50 percent kill): 350 mg/kgZHYGAM 29,395,1983
oral/mouse lethal dose (50 percent kill): 350 mg/kgZHYGAM 29,395,1983
oral/rat lethal dose (50 percent kill): 270 mg/kgZHYGAM 29,395,1983
skin/rat lethal dose (50 percent kill): 463 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Lung, Thorax, or Respiration: Cyanosis

Kidney, Ureter, and Bladder: Other changes in urine composition		NTIS** OTS0544321

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWREPTED 29,10,2010

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M2689; Number of Industries 1; Total Number of Facilities 4; Number of Occupations 3; Total Number of Employees Exposed 413
National Occupational Hazard Survey 1974Hazard Code M2689; Number of Industries 1; Total Number of Facilities 15; Number of Occupations 1; Total Number of Employees Exposed 29

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, PROPOSED RULEFEREAC 47,27009,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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