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Registry of Toxic Effects of Chemical Substances (RTECS)

Toluene, dinitro-

RTECS #

XT1300000

CAS #

25321-14-6

Updated

September 201

Molecular Weight

182.15

Molecular Formula

C7H6N2O4

Synonyms

Benzene, methyldinitro-
Dinitrophenylmethane
Dinitrotoluene
Dinitrotoluene (ACGIH)
Methyldinitrobenzene
Toluene, ar,ar-dinitro-

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
morphological transformoral/rat294 mg/kg/3W-continuousCRNGDP 7,1797,1986
Unscheduled DNA Synthesisoral/rat35 mg/kgEMMUEG 14,155,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1050 mg/kg (7-20D pregnant)Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Effects on newborn: Delayed effects		CIIT** DOCKET #10992,1982
oral/rat 196 mg/kg (7-20D pregnant)Reproductive: Effects on newborn: BehavioralCIIT** DOCKET #10992,1982
oral/rat 2100 mg/kg (7-20D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)FAATDF 5,948,1985
oral/rat 1400 mg/kg (7-20D pregnant)Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)FAATDF 5,948,1985

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 12775 mg/kg/1Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors		PAACA3 24,91,1983

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/guinea pig lethal dose (50 percent kill): 1300 mg/kgBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory stimulation		GISAAA 42(10),17,1977
oral/mouse lethal dose (50 percent kill): 750 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea		SRTCAC 36(1-4),10,1989

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 4550 µg/kg/26W- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases		GISAAA 42(10),17,1977
oral/rat lowest published toxic dose: 4200 mg/kg/4W- intermittentEndocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0546413

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.2 mg/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWTOLED5 127,321,2002
TOXICOLOGY REVIEWMUREAV 588,88,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1.5 mg/m3 (skin)DTLVS* 3,93,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 1.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1.5 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.15 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.15 mg/m3, skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.2 mg/m3, skin, NOV2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.15 mg/m3, skin, sen, NOV2011
Occupational Exposure Limit-INDIAtime-weighted average 1.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 1.5 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1.5 mg/m3;short term exposure limit 5 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1.5 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.15 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,2 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 5 mg/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 0.15 mg/m3;short term exposure limit 0.3 mg/m3, Carcinogen, Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDcarc 2, JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1.5 mg/m3, Skin, JAN1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DINITROTOLUENE-air10H Carcinogen time-weighted average 1.5 mg/m3 (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-human
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN #44

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