Registry of Toxic Effects of Chemical Substances (RTECS)
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Toxaphene
RTECS #
XW5250000CAS #
8001-35-2; 8022-04-6Updated
September 201Molecular Weight
413.80Molecular Formula
C10H10Cl8Synonyms
Agricide maggot killer (F)Alltox
Anatox
Attac 4-2
Attac 4-4
Attac 6
Attac 6-3
Attac 8
Camphechlor
Camphochlor
Camphoclor
Camphofene huileux
Chlorinated camphene
Chlorinated camphene (OSHA)
Chlorinated camphene 60% (ACGIH)
Chlorinated camphene, technical
Clor Chem T-590
Compound 3956
Cristoxo 90
ENT 9,735
Estonox
Fasco-terpene
Geniphene
Hercules 3956
Kamfochlor
Latka 3956 (Czech)
M 5055
Melipax
NCI-C00259
PCC
Phenacide
Phenatox
Polychlorocamphene
RCRA waste number P123
Strobane T-90
Strobane-T
Toxafeen (Dutch)
Toxakil
Toxaphen (German)
Toxaphene (OSHA)
Toxaphene fume
Toxon 63
Toxyphen
Vertac toxaphene 90
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| skin /mammal (species unspecified) | 500 mg | moderate | JAMAAP 149,1135,1952 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | multiple/other fish | 1500 µg/kg/10D-continuous | BIZNAT 94,441,1975 |
| micronucleus test | liver/human | 20 µmol/L/24H | TXCYAC 198,315,2004 |
| morphological transform | embryo/mouse | 12400 µg/L | PMRSDJ 5,659,1985 |
| mutation in microorganisms | /Salmonella typhimurium | 100 µg/plate (+enzymatic activation step) | ENMUDM 8(Suppl 7),1,1986 |
| mutation in microorganisms | /Salmonella typhimurium | 500 µg/plate (-enzymatic activation step) | SCIEAS 205,591,1979 |
| phage inhibition capacity | /Escherichia coli | 100 µmol/L | MUREAV 182,193,1987 |
| phage inhibition capacity | /Escherichia coli | 0.381 mmol/L (+enzymatic activation step) | EMMUEG 36,206,2000 |
| sister chromatid exchange | lung/hamster | 5 mg/L | MUREAV 230,29,1990 |
| sister chromatid exchange | lymphocyte/human | 10 µmol/L | ARTODN 52,221,1983 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 280 mg/kg (10W male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | GISAAA 45(5),14,1980 |
| oral/rat | 900 µg/kg (5-22D pregnant) | Reproductive: Effects on newborn: Behavioral | AECTCV 9,247,1980 |
| oral/rat | 150 mg/kg (7-16D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | BECTA6 15,660,1976 |
| oral/rat | 250 mg/kg (7-16D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | BECTA6 15,660,1976 |
| oral/mouse | 375 mg/kg (8-12D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | JTEHD6 10,541,1982 |
| oral/mouse | 100 mg/kg (8D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | TCMUD8 5,3,1985 |
| oral/mouse | 375 mg/kg (8-12D pregnant) | Reproductive: Effects on newborn: Physical Reproductive: Effects on newborn: Delayed effects | TCMUD8 4,403,1984 |
| oral/rat | 88 mg/kg (22D pregnant) | Reproductive: Other developmental abnormalities | VCVPS* -,304,1998 |
| oral/hamster | 64 mg/kg (16D pregnant) | Reproductive: Other developmental abnormalities | VCVPS* -,304,1998 |
| oral/rat | 280 mg/kg (10W prior to copulation) | Reproductive: Other developmental abnormalities | VCVPS* -,304,1998 |
| oral/hamster | 280 mg/kg (10W prior to copulation) | Reproductive: Other developmental abnormalities | VCVPS* -,304,1998 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published toxic dose: 6600 mg/kg/80W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | NCITR* NCI-TR-37,1979 |
| oral/mouse | toxic dose: 13 gm/kg/80W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | NCITR* NCI-TR-37,1979 |
| oral/rat | lowest published toxic dose: 30 gm/kg/80W- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Blood: Lymphoma including Hodgkin's disease | NCITR* NCI-TR-37,1979 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | Lowest published lethal concentration: 2000 mg/m3/2H | JAMAAP 149,1135,1952 | |
| inhalation/mouse | lethal concentration (50 percent kill): 2000 mg/m3/2H | Behavioral: Tetany Lung, Thorax, or Respiration: Respiratory obstruction Nutritional and Gross Metabolic: Body temperature decrease | VCVPS* -,302,1998 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 42 mg/kg | JAFCAU 22,653,1974 | |
| intraperitoneal/rat | lowest published lethal dose: 70 mg/kg | Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea | BECTA6 19,47,1978 |
| intraperitoneal/rat | lowest published toxic dose: 165.5 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Metabolism (intermediary): Other | GEPHDP 18,165,1987 |
| oral/cat | lowest published toxic dose: 70 mg/kg | Behavioral: Tetany Behavioral: Muscle contraction or spasticity | VCVPS* -,302,1998 |
| oral/Dog | lethal dose (50 percent kill): 15 mg/kg | VCVGH* -,556,1990 | |
| oral/Dog | lethal dose (50 percent kill): 15 mg/kg | Behavioral: Tetany Behavioral: Muscle contraction or spasticity | VCVPS* -,302,1998 |
| oral/duck | lethal dose (50 percent kill): 31 mg/kg | DOEAAH 35,25,1979 | |
| oral/guinea pig | lethal dose (50 percent kill): 250 mg/kg | Behavioral: Tetany Lung, Thorax, or Respiration: Respiratory obstruction Nutritional and Gross Metabolic: Body temperature decrease | VCVPS* -,302,1998 |
| oral/guinea pig | lethal dose (50 percent kill): 250 mg/kg | VCVGH* -,556,1990 | |
| oral/hamster | lethal dose (50 percent kill): 200 mg/kg | TXAPA9 48,A192,1979 | |
| oral/human | lowest published lethal dose: 28 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Behavioral: Coma | 34ZIAG -,598,1969 |
| oral/human | lowest published lethal dose: 60 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | VCVPS* -,303,1998 |
| oral/man | lowest published lethal dose: 29 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Cyanosis Lung, Thorax, or Respiration: Other changes | CMEP** -,-,1956 |
| oral/mouse | lethal dose (50 percent kill): 45 mg/kg | Behavioral: Tetany Lung, Thorax, or Respiration: Respiratory obstruction Nutritional and Gross Metabolic: Body temperature decrease | VCVPS* -,302,1998 |
| oral/mouse | lethal dose (50 percent kill): 45 mg/kg | VCVGH* -,556,1990 | |
| oral/rabbit | lethal dose (50 percent kill): 25 mg/kg | VCVGH* -,556,1990 | |
| oral/rabbit | lethal dose (50 percent kill): 25 mg/kg | Behavioral: Tetany Lung, Thorax, or Respiration: Respiratory obstruction Nutritional and Gross Metabolic: Body temperature decrease | VCVPS* -,302,1998 |
| oral/rat | lethal dose (50 percent kill): 40 mg/kg | Behavioral: Tetany Lung, Thorax, or Respiration: Respiratory obstruction Nutritional and Gross Metabolic: Body temperature decrease | VCVPS* -,302,1998 |
| oral/rat | lethal dose (50 percent kill): 40 mg/kg | VCVGH* -,556,1990 | |
| oral/rat | lowest published toxic dose: 300 mg/kg | VCVPS* -,302,1998 | |
| oral/rat | lowest published toxic dose: 300 mg/kg | Behavioral: Tetany Behavioral: Muscle contraction or spasticity | VCVPS* -,302,1998 |
| parenteral/rat | lethal dose (50 percent kill): 90 mg/kg | DEVEAA 26,5,1972 | |
| skin/human | lowest published toxic dose: 657 mg/kg | Skin: After systemic exposure: Dermatitis, allergic | CMEP** -,1,1956 |
| skin/mouse | lethal dose (50 percent kill): 250 mg/kg | VCVGH* -,556,1990 | |
| skin/rabbit | lethal dose (50 percent kill): 250 mg/kg | VCVGH* -,556,1990 | |
| skin/rabbit | lethal dose (50 percent kill): 1025 mg/kg | Behavioral: Excitement Behavioral: Food intake (animal) Vascular: Regional or general arteriolar or venous dilation | JEENAI 46,702,1953 |
| skin/rat | lethal dose (50 percent kill): 250 mg/kg | VCVGH* -,556,1990 | |
| skin/rat | lethal dose (50 percent kill): 940 mg/kg | Behavioral: Alteration of classical conditioning Behavioral: Tremor Lung, Thorax, or Respiration: Dyspnea | VCVPS* -,303,1998 |
| unreported route/man | lowest published lethal dose: 44 mg/kg | 85DCAI 2,73,1970 | |
| unreported route/mouse | lethal dose (50 percent kill): 45 mg/kg | CYGEDX 8(1),23,1974 | |
| unreported route/rat | lethal dose (50 percent kill): 240 mg/kg | CYGEDX 8(1),23,1974 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/human | lowest published toxic concentration: 20 mg/m3/3Y- intermittent | Cardiac: Arrythmias (indlucing changes in conduction) Behavioral: Wakefulness Behavioral: Headache | VCVPS* -,304,1998 |
| intraperitoneal/rat | lowest published toxic dose: 175 mg/kg/7D- intermittent | Liver: Other changes Biochemical: Metabolism (intermediary): Other | TXAPA9 19,234,1971 |
| oral/Dog | lowest published toxic dose: 385 mg/kg/13W- intermittent | Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | FAATDF 7,406,1986 |
| oral/guinea pig | lowest published toxic dose: 120 mg/kg/60D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JEBIDP 13,315,1992 |
| oral/hamster | lowest published toxic dose: 280 mg/kg/10W- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes | VCVPS* -,304,1998 |
| oral/hamster | lowest published toxic dose: 64 mg/kg/16D- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes | VCVPS* -,304,1998 |
| oral/monkey | lowest published toxic dose: 95 mg/kg/34W- intermittent | Immunological Including Allergic: Decrease in cellular immune response | TOXID9 54,335,2000 |
| oral/monkey | lowest published toxic dose: 6.3 mg/kg/9W- continuous | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | FCTOD7 39,467,2001 |
| oral/monkey | lowest published toxic dose: 392 mg/kg/70W- continuous | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Skin: After systemic exposure: Dermatitis, other Skin and Appendages: Other: Nails | FCTOD7 39,467,2001 |
| oral/monkey | lowest published toxic dose: 148 mg/kg/53W- intermittent | Immunological Including Allergic: Decrease in humoral immune response | FCTOD7 39,947,2001 |
| oral/monkey | lowest published toxic dose: 296 mg/kg/46W- intermittent | Immunological Including Allergic: Decrease in cellular immune response Immunological Including Allergic: Decrease in humoral immune response | FCTOD7 39,947,2001 |
| oral/monkey | lowest published toxic dose: 268 mg/kg/34W- continuous | Immunological Including Allergic: Decrease in humoral immune response | FCTOD7 39,1243,2001 |
| oral/monkey | lowest published toxic dose: 364 mg/kg/52W- continuous | Endocrine: Changes in spleen weight Endocrine: Changes in thymus weight | FCTOD7 39,1243,2001 |
| oral/monkey | lowest published toxic dose: 364 mg/kg/52W- continuous | Liver: Changes in liver weight Endocrine: Effect on menstrual cycle Endocrine: Changes in spleen weight | FCTOD7 39,1243,2001 |
| oral/quail | lowest published toxic dose: 126 mg/kg/18W- continuous | Endocrine: Changes in adrenal weight Endocrine: Changes in thyroid weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | POSCAL 53,125,1974 |
| oral/rabbit | lowest published toxic dose: 456.2 mg/kg/26W- intermittent | Musculoskeletal: Other changes | VCVPS* -,304,1998 |
| oral/rat | lowest published toxic dose: 280 mg/kg/10W- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes | VCVPS* -,304,1998 |
| oral/rat | lowest published toxic dose: 88 mg/kg/22D- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes | VCVPS* -,304,1998 |
| oral/rat | lowest published toxic dose: 1875 mg/kg/25D- intermittent | Endocrine: Other changes | RTOPDW 24,184,1996 |
| oral/rat | lowest published toxic dose: 4186 mg/kg/13W- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | FAATDF 7,406,1986 |
| oral/rat | lowest published toxic dose: 328 mg/kg/39W- continuous | Liver: Other changes | AMPLAO 64,614,1957 |
| oral/rat | lowest published toxic dose: 120 mg/kg/4W- intermittent | Behavioral: Somnolence (general depressed activity) Behavioral: Food intake (animal) Immunological Including Allergic: Decrease in cellular immune response | VCVPS* -,304,1998 |
| unreported route/chicken | lowest published toxic dose: 480 mg/kg/10D- intermittent | Brain and Coverings: Changes in surface EEG Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Somnolence (general depressed activity) | FIZHDO 27,557,1981 |
| unreported route/mammal (species unspecified) | lowest published toxic dose: 73 gm/kg/2Y- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVPS* -,304,1998 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.5 mg/m3;short term exposure limit 1 mg/m3 (skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 79,-,2000 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 79,-,2000 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 79,-,2000 |
| TOXICOLOGY REVIEW | ANAEA3 35,165,1975 | |
| TOXICOLOGY REVIEW | DTTIAF 80,485,1973 | |
| TOXICOLOGY REVIEW | RREVAH 56,107,1975 | |
| TOXICOLOGY REVIEW | MUREAV 567,227,2004 | |
| TOXICOLOGY REVIEW | MUREAV 567,347,2004 | |
| TOXICOLOGY REVIEW | ENTOX* -,334,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,207,2005 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | HETOEA 25,413,2006 | |
| TOXICOLOGY REVIEW | JTEHD6 7,1,2004 | |
| TOXICOLOGY REVIEW | MUREAV 543,251,2003 | |
| TOXICOLOGY REVIEW | HTOPA* 1,501,2002 | |
| TOXICOLOGY REVIEW | IMEMDT 79,569, | |
| TOXICOLOGY REVIEW | FESTAS 90,911,2008 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Cancelled | RBREV* -,214,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.5 mg/m3 (skin) | DTLVS* 3,45,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 0.5 mg/m3, Skin, JAN1993 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.5 mg/m3, short term exposure limit 1 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.5 mg/m3;KZW 5 mg/m3, inhal, skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.5 mg/m3, short term exposure limit 1 mg/m3, Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.5 mg/m3, skin, carc, MAY2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.5 mg/m3, Skin, C3 Carcinogen, FEB2006 | |
| Occupational Exposure Limit-HUNGARY | Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.5 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.5 mg/m3, short term exposure limit 1 mg/m3, skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.5 mg/m3 (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.5 mg/m3; short term exposure limit 1 mg/m3, skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.5 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0.5 mg/m3; short term exposure limit 1 mg/m3, JUL2005 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 25 ppm (150 mg/m3);short term exposure limit 50 ppm (300 mg/m3), JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.5 mg/m3, carc 2, inhal, skin, JAN2011 | |
| Occupational Exposure Limit-THAILAND | time-weighted average 0.5 mg/m3, JAN1993 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.5 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.5 mg/m3, Skin, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 0.5 mg/m3, Skin, JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.5 mg/m3 (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORINATED CAMPHENE-air | Carcinogen lowest feasible conc. | NIOSH* DHHS #92-100,1992 |
| National Occupational Hazard Survey 1974 | Hazard Code 73500; Number of Industries 1; Total Number of Facilities 68; Number of Occupations 2; Total Number of Employees Exposed 203 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| ATSDR TOXICOLOGY PROFILE (NTIS** PB/97/121057/AS) | |
| EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Bioassay (feed);clear evidence:mouse | NCITR* NCI-TR-37,1979 |
| NCI Carcinogenesis Bioassay (feed);equivocal evidence:rat | NCITR* NCI-TR-37,1979 |
| NIOSH Analytical Method, 1994: Chlorinated camphene, 5039 | |
| NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen | |
| On EPA IRIS database |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division