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Registry of Toxic Effects of Chemical Substances (RTECS)

as-Triazin-5(4H)-one, 4-amino-6-tert-butyl-3-(methylthio)-

RTECS #

XZ2990000

CAS #

21087-64-9

Updated

September 201

Molecular Weight

214.32

Molecular Formula

C8H14N4OS

Synonyms

1,2,4-Triazin-5(4H)-one, 4-amino-6-(1,1-dimethylethyl)-3-(methylthio)-
1,2,4-Triazin-5-one, 4-amino-6-tert-butyl-3-(methylthio)-
4-Amino-6-(1,1-dimethylethyl)-3-(methylthio)-1,2,4-triazin-5(4H)-one
4-Amino-6-tert-butyl-3-(methylthio)-1,2,4-triazin-5-one
4-Amino-6-tert-butyl-3-methylthio-as-triazin-5-one
BAY 61597
BAY dic 1468
Bayer 6159H
Bayer 6443H
Bayer 94337
DIC 1468
Lexone
Lexone 4L
Lexone DF
Metribuzin
Metribuzin (ACGIH)
NTN 70
Sencor
Sencor 4
Sencor DF
Sencoral
Sencorer
Sencorex
Zenkor

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)NNGADV 12,127,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lethal concentration: >860 mg/m3/4H85INA8 6,1042,1991
inhalation/rat lethal concentration (50 percent kill): >860 mg/m3/4HNNGADV 12,127,1987
intraperitoneal/mouse lethal dose (50 percent kill): 210 mg/kgBehavioral: Somnolence (general depressed activity)PCBPBS 23,123,1984
intraperitoneal/rat lethal dose (50 percent kill): 239 mg/kgNNGADV 12,127,1987
oral/cat lethal dose (50 percent kill): >500 mg/kg85JFAN A280,1983
oral/guinea pig lethal dose (50 percent kill): 250 mg/kg85DPAN -,-,1971/1976
oral/mouse lethal dose (50 percent kill): 564 mg/kgNNGADV 12,127,1987
oral/quail lethal dose (50 percent kill): 164 mg/kgPEMNDP 8,573,1987
oral/rat lethal dose (50 percent kill): 1100 mg/kgFMCHA2 -,C204,1991
skin/mouse lethal dose (50 percent kill): >1 gm/kgNNGADV 12,127,1987
skin/rabbit lethal dose (50 percent kill): >20 gm/kgFMCHA2 -,C204,1991
skin/rat lethal dose (50 percent kill): 2 gm/kg85JCAE -,1001,1986
subcutaneous/mouse lethal dose (50 percent kill): 367 mg/kgNNGADV 12,127,1987
subcutaneous/rat lethal dose (50 percent kill): 814 mg/kgNNGADV 12,127,1987
unreported route/quail lethal dose (50 percent kill): 168 mg/kgFMCHA2 -,C204,1991

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 27375 mg/kg/2Y- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		NNGADV 12,127,1987
oral/Dog lowest published toxic dose: 27.3 gm/kg/104W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		HBPTO* 2,1512,2001
oral/mouse lowest published toxic dose: 65.7 gm/kg/78W- continuousKidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight

Blood: Other changes		HBPTO* 2,1514,2001
oral/rat lowest published toxic dose: 10.95 gm/kg/2Y- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		HBPTO* 2,1514,2001
oral/rat lowest published toxic dose: 10.95 gm/kg/2Y- continuousReproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)		HBPTO* 2,1514,2001
oral/rat lowest published toxic dose: 10.92 gm/kg/104W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		HBPTO* 2,1512,2001
oral/rat lowest published toxic dose: 64800 µg/kg/15W- continuousBrain and Coverings: Other degenerative changesJTEHD6 30,209,1990
oral/rat lowest published toxic dose: 4550 mg/kg/26W- intermittentImmunological Including Allergic: Increased immune responseGISAAA 52(11),76,1987
oral/rat lowest published toxic dose: 13140 mg/kg/2Y- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainNNGADV 12,127,1987

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWFEREAC 71,43906,2006
TOXICOLOGY REVIEWFEREAC 72,39318,2007
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWHTOPA* 1,501,2002

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,133,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 mg/m3;KZW 10 mg/m3, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 mg/m3, MAY2011
Occupational Exposure Limit-FRANCEVME 5 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 5 mg/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 5 mg/m3, JUL2005
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METRIBUZIN-air10H time-weighted average 5 mg/m3NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

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