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Registry of Toxic Effects of Chemical Substances (RTECS)

Beryllium nitrate

RTECS #

DS3675000

CAS #

13597-99-4

Updated

September 201

Molecular Weight

133.03

Molecular Formula

BeN2O6

Synonyms

Beryllium dinitrate
Nitric acid, beryllium salt

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA repair/Bacillus subtilis750 µg/discMUREAV 264,163,1991
sister chromatid exchangelung/hamster31 mg/LMUREAV 264,163,1991

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intramuscular/rat 50 mg/kg (13D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)		ARTODN 76,442,2002
intratesticular/rat 10803 µg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct		JRPFA4 7,21,1964
intravenous/rat 31 µg/kg (18D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Hepatobiliary system		56ZJAL 3,129,1994

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intramuscular/rat lowest published toxic dose: 50 mg/kgBehavioral: Somnolence (general depressed activity)JJATDK 20,313,2000
intraperitoneal/guinea pig lowest published lethal dose: 100 mg/kgEQSSDX 1,1,1975
intraperitoneal/mouse lethal dose (50 percent kill): 500 µg/kgEQSSDX 1,1,1975
intravenous/mouse lethal dose (50 percent kill): 3160 µg/kgCUSCAM 55,899,1986
subcutaneous/frog lowest published lethal dose: 1041 mg/kgRDWU** -,-,1930
subcutaneous/mouse lowest published lethal dose: 50 mg/kgRDWU** -,-,1930

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intramuscular/rat lowest published toxic dose: 1500 mg/kg/30D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Other carbohydrates		JEBIDP 12,63,1991
intraperitoneal/rat lowest published toxic dose: 28 mg/kg/28D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects		FCTOD7 46,3069,2008
intraperitoneal/rat lowest published toxic dose: 28 mg/kg/28D- intermittentLiver: Multiple effects

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects		FCTOD7 46,3069,2008
intraperitoneal/rat lowest published toxic dose: 28 mg/kg/28D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Endocrine: Hypoglycemia		JAPTO* 28,44,2008

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.00005 mg(Be)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 58,41,1993
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 58,41,1993
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 58,41,1993
TOXICOLOGY REVIEWMUREAV 533,99,2003
TOXICOLOGY REVIEWHBTME* ,415,2007

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.002 mg(Be)/m3, Carcinogen, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.002 mg(Be)/m3, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.001 mg(Be)/m3 (dust), carc, MAY2011
Occupational Exposure Limit-FRANCEVME 0.002 mg(Be)/m3, C2 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYceiling concentration 0.002 mg(Be)/m3, Carcinogen, SEP2000
Occupational Exposure Limit-INDIAtime-weighted average 0.002 mg(Be)/m3, Carcinogen, JAN1993
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.002 mg(Be)/m3, 2A carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.002 mg(Be)/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.002 mg(Be)/m3, carcinogen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.001 mg(Be)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.001 mg(Be)/m3, MAC(short term exposure limit) 0.003 mg(Be)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.001 mg(Be)/m3, short term exposure limit 0.003 mg(Be)/m3, Carcinogen, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.002 mg(Be)/m3, Carcinogen, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.002 mg(Be)/m3, carc 1, inhal, sen, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.002 mg(Be)/m3, short term exposure limit 0.005 mg(Be)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.002 mg(Be)/m3, carc, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BERYLLIUM-airCarcinogen not to exceed 0.0005 mg(Be)/m3NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen

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