Registry of Toxic Effects of Chemical Substances (RTECS)
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Beryllium oxide
RTECS #
DS4025000CAS #
1304-56-9Updated
September 201Molecular Weight
25.01Molecular Formula
BeOSynonyms
BerylliaBeryllium monoxide
Thermalox
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intratracheal/rat | 139 mg/kg (3D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Other developmental abnormalities | GISAAA 51(8),44,1986 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| implant/rabbit | lowest published toxic dose: 10 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Musculoskeletal: Tumors | ARPAAQ 88,89,1969 |
| inhalation/rabbit | lowest published toxic concentration: 17 mg/m3/5H/48W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Musculoskeletal: Tumors | AMPLAO 51,473,1951 |
| inhalation/rat | lowest published toxic concentration: 28 mg/m3/17W- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | IMSUAI 40,23,1971 |
| intratracheal/rat | lowest published toxic dose: 75 mg/kg/15W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | FKIZA4 71,19,1980 |
| intratracheal/rat | toxic dose: 169 mg/kg/2W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | AMIHAB 19,190,1959 |
| intratracheal/rat | toxic dose: 79 mg/kg/15W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | SAIGBL 20,230,1978 |
| intravenous/rabbit | toxic dose: 625 mg/kg/25W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Musculoskeletal: Tumors | AMSHAR 25,99,1977 |
| intravenous/rabbit | toxic dose: 500 mg/kg/48W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Musculoskeletal: Tumors | PEXTAR 2,203,1961 |
| intravenous/rabbit | lowest published toxic dose: 500 mg/kg/6W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Musculoskeletal: Tumors | FEPRA7 5,221,1946 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/human | lowest published toxic concentration: 0.67 mg/m3 | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Body temperature increase | VCVN1* -,95,1988 |
| inhalation/mammal (species unspecified) | lowest published toxic concentration: 0.2 mg/m3/1H | Lung, Thorax, or Respiration: Other changes Immunological Including Allergic: Autoimmune (multiple organ involvement) | VCVN1* -,94,1988 |
| intratracheal/rat | lowest published toxic dose: 55.6 mg/kg | Lung, Thorax, or Respiration: Changes in lung weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | TPKVAL 9,187,1967 |
| intratracheal/rat | lowest published toxic dose: 55.6 mg/kg | Cardiac: Cardiomyopathy including infarction Cardiac: Changes in coronary arteries Vascular: Other changes | TPKVAL 8,27,1966 |
| intratracheal/rat | lowest published toxic dose: 5 mg/kg | Lung, Thorax, or Respiration: Other changes Lung, Thorax, or Respiration: Bronchogenic carcinoma Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVN1* -,94,1988 |
| oral/mouse | lethal dose (50 percent kill): 2062 mg/kg | VCVN1* -,93,1988 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/Dog | lowest published toxic concentration: 3.6 mg/m3/40D- intermittent | Blood: Macrocytosis | HBTME* -,415,2007 |
| inhalation/rat | lowest published toxic concentration: 2 mg/m3/110D- intermittent | Lung, Thorax, or Respiration: Fibrosis (interstitial) Liver: Hepatitis (hepatocellular necrosis), zonal Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN1* -,95,1988 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.00005 mg(Be)/m3 | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed human carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 1,17,1972 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 23,143,1980 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 58,41,1993 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Sufficient Evidence | IMEMDT 58,41,1993 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 1 | IMEMDT 58,41,1993 |
| TOXICOLOGY REVIEW | CTOXAO 6,497,1973 | |
| TOXICOLOGY REVIEW | FCTXAV 9,105,1971 | |
| TOXICOLOGY REVIEW | MUREAV 533,99,2003 | |
| TOXICOLOGY REVIEW | HBTME* ,415,2007 | |
| TOXICOLOGY REVIEW | HTOPA* 1,701,2002 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 0.002 mg(Be)/m3, JAN1993 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.002 mg(Be)/m3, Carcinogen, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.001 mg(Be)/m3 (dust), carc, MAY2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.002 mg(Be)/m3, C2 Carcinogen, FEB2006 | |
| Occupational Exposure Limit-HUNGARY | ceiling concentration 0.002 mg(Be)/m3, Carcinogen, SEP2000 | |
| Occupational Exposure Limit-INDIA | time-weighted average 0.002 mg(Be)/m3, Carcinogen, JAN1993 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 0.002 mg(Be)/m3, 2A carc, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.002 mg(Be)/m3, 2006 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.002 mg(Be)/m3, carcinogen, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.001 mg(Be)/m3, JAN1999 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 0.001 mg(Be)/m3, MAC(short term exposure limit) 0.003 mg(Be)/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | time-weighted average 0.001 mg(Be)/m3, short term exposure limit 0.003 mg(Be)/m3, Carcinogen, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 0.002 mg(Be)/m3, Carcinogen, Sen, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.002 mg(Be)/m3, carc 1, inhal, sen, JAN2011 | |
| Occupational Exposure Limit-THAILAND | time-weighted average 0.002 mg(Be)/m3, short term exposure limit 0.005 mg(Be)/m3, JAN1993 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.002 mg(Be)/m3, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 0.002 mg(Be)/m3, JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.002 mg(Be)/m3, carc, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.002 mg(Be)/m3 | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.002 mg(Be)/m3 | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.002 mg(Be)/m3 | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.002 mg(Be)/m3 | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BERYLLIUM-air | Carcinogen not to exceed 0.0005 mg(Be)/m3 | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code X3577; Number of Industries 6; Total Number of Facilities 66; Number of Occupations 9; Total Number of Employees Exposed 4305; Total Number of Female Employees Exposed 849 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat | |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| NTP 11th Report on Carcinogens,2004:Known to be human carcinogen |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division