Registry of Toxic Effects of Chemical Substances (RTECS)
2,3-Butanedione
RTECS #
EK2625000CAS #
431-03-8Updated
September 201Molecular Weight
86.10Molecular Formula
C4H6O2Synonyms
2,3-Butadione2,3-Diketobutane
Biacetyl
Diacetyl
Dimethyl diketone
Dimethylglyoxal
Glyoxal, dimethyl-
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
skin /rabbit | 500 mg/24H | moderate | FCTXAV 17,765,1979 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
mutation in mammalian somatic cells | other cell types/mouse | 200 mg/L/4H (+enzymatic activation step) | FCTOD7 46,2928,2008 |
mutation in microorganisms | /Salmonella typhimurium | 1 mg/plate (+enzymatic activation step) | MUREAV 67,367,1979 |
Unscheduled DNA Synthesis | oral/rat | 1500 mg/kg | JJCREP 76,809,1985 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | lowest published toxic concentration: 198.4 ppm/6H | Olfaction: Other olfaction effects Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOXID9 78,438,2004 |
inhalation/rat | lowest published toxic concentration: 294.6 ppm/6H | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOXID9 78,438,2004 |
inhalation/rat | lowest published toxic concentration: 294.6 ppm/6H | Lung, Thorax, or Respiration: Other changes | TOPADD 36,330,2008 |
inhalation/rat | lowest published toxic concentration: 224 ppm/1H | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | TOPADD 36,330,2008 |
inhalation/rat | lowest published toxic concentration: 198.4 ppm/6H | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | TOPADD 36,330,2008 |
inhalation/rat | lowest published toxic concentration: 356 ppm/1H | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOPADD 36,330,2008 |
inhalation/rat | lowest published toxic concentration: 92.9 ppm/15M | Olfaction: Other olfaction effects | TOPADD 36,330,2008 |
intraperitoneal/rat | lethal dose (50 percent kill): 400 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Change in motor activity (specific assay) Vascular: Regional or general arteriolar or venous dilation | FCTXAV 7,571,1969 |
oral/guinea pig | lethal dose (50 percent kill): 990 mg/kg | Behavioral: Ataxia Behavioral: Coma Lung, Thorax, or Respiration: Dyspnea | FCTXAV 2,327,1964 |
oral/rat | lethal dose (50 percent kill): 3000 mg/kg | VCVGK* -,448,1994 | |
oral/rat | lethal dose (50 percent kill): 1580 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold | FCTXAV 2,327,1964 |
skin/rabbit | lethal dose (50 percent kill): >5 gm/kg | FCTXAV 17,765,1979 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mouse | lowest published toxic concentration: 200 ppm/5D- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TOXID9 90,210,2006 |
oral/rat | lowest published toxic dose: 48600 mg/kg/90D- intermittent | Liver: Changes in liver weight Endocrine: Changes in adrenal weight Blood: Pigmented or nucleated red blood cells | FCTXAV 7,571,1969 |
oral/rat | lowest published toxic dose: 48600 mg/kg/90D- intermittent | Gastrointestinal: Ulceration or bleeding from stomach Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight | VCVGK* -,448,1994 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.01 ppm;short term exposure limit 0.02 ppm | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
NTP Carcinogenesis studies; selected, October 2000 |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division