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Registry of Toxic Effects of Chemical Substances (RTECS)

Chromium(III) chloride, hexahydrate (1:3:6)

RTECS #

GB5450000

CAS #

10060-12-5

Updated

July 2013

Molecular Weight

266.47

Molecular Formula

Cl3Cr·6H2O

Synonyms

Chlorid chromity hexahydrat (Czech)
Chromic chloride hexahydrate
Chromium chloride, hexahydrate (8CI,9CI)
Chromium sesquichloride
Chromium trichloride hexahydrate
Hexaaquachromium (III) chloride
Hexaaquachromium chloride

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human2500 µg/LMUREAV 191,207,1987
Cytogenetic Analysisleukocyte/human400 mg/LSAIGBL 18,136,1976
DNA adductintraperitoneal/rat80 mg/kgCNREA8 45,1146,1985
DNA adductkidney/hamster500 mg/LCBINA8 37,309,1981
DNA Damagelung/hamster10 µmol/LMUREAV 117,279,1983
DNA Damageother cell types/cattle0.01 mmol/L/1HEVHPAZ 108,399,2000
DNA repair/Escherichia coli31 µg/wellMUREAV 133,161,1984
other mutation test systemsother cell types/human500 mg/LBJCAAI 44,219,1981
other mutation test systemskidney/hamster500 mg/LCBINA8 37,309,1981
sister chromatid exchangelung/hamster39 mg/LCRNGDP 4,605,1983
sister chromatid exchangefibroblast/hamster32 mg/LMUREAV 104,141,1982

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 134 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Central nervous system		TXCYAC 26,257,1983
intraperitoneal/mouse 266 mg/kg (1D male)Reproductive: Other reproductive system tumorsTXAPA9 158,161,1999
intraperitoneal/mouse 266.5 mg/kg (1D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Effects on newborn: Biochemical and metabolic		EVHPAZ 110,801,2002
intraperitoneal/mouse 26.6 mg/kg (1D male)Reproductive: Effects on newborn: Biochemical and metabolicEVHPAZ 110,801,2002

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 285 mg/kgTXAPA9 63,461,1982
intraperitoneal/mouse lowest published toxic dose: 266.47 mg/kgEndocrine: Hyperglycemia

Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		EVHPAZ 110,801,2002
intravenous/frog lowest published lethal dose: 374 mg/kgAIPTAK 62,330,1939
intravenous/mouse lowest published lethal dose: 1602 mg/kgAIPTAK 62,330,1939
intravenous/rabbit lowest published lethal dose: 576 mg/kgAIPTAK 62,330,1939
oral/mouse lethal dose (50 percent kill): 2.39 gm/kgBehavioral: Alteration of classical conditioningFCTOD7 50,1623,2012
oral/mouse lowest published lethal dose: 4.8 gm/kgEye: Hemorrhage

Behavioral: Alteration of classical conditioning		FCTOD7 50,1623,2012
oral/mouse lowest published toxic dose: 2.4 gm/kgEndocrine: Changes in spleen weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		FCTOD7 50,1623,2012
oral/rat lowest published toxic dose: 895 mg/kgBiochemical: Metabolism (intermediary): Lipids including transportTXCYAC 180,5,2002
oral/rat lethal dose (50 percent kill): 1790 mg/kgMarJV# 29MAR1977

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 219.8 mg/kg/2W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases		FCTOD7 50,1623,2012

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEW85DHAX Cr,22,1974

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 mg(Cr)/m3DTLVS* 3,35,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 mg(Cr)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 mg(Cr)/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.005 mg(Cr)/m3, MAY2011
Occupational Exposure Limit-ECtime-weighted average 2 mg(Cr)/m3, FEB2006
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.5 mg(Cr)/m3, a2 sen, s1 sen, MAY2012
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 mg(Cr)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.5 mg(Cr)/m3, JAN1999
Occupational Exposure Limit-POLANDtime-weighted average 0.5 mg(Cr)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.01 mg/m3, short term exposure limit 0.03 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg(Cr)/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg(Cr)/m3, inhal, sen, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.5 mg(Cr)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.5 mg(Cr)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.5 mg(Cr)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.5 mg(Cr)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.5 mg(Cr)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X9134; Number of Industries 1; Total Number of Facilities 41; Number of Occupations 2; Total Number of Employees Exposed 573; Total Number of Female Employees Exposed 203

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte

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