Registry of Toxic Effects of Chemical Substances (RTECS)
Cobalt(2+) oxide
RTECS #
GG2800000CAS #
1307-96-6Updated
September 201Molecular Weight
74.93Molecular Formula
CoOSynonyms
C.I. 77322C.I. Pigment Black 13
Cobalt Black
Cobalt monooxide
Cobalt monoxide
Cobaltous oxide
Monocobalt oxide
Zaffre
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intramuscular/rat | lowest published toxic dose: 135 mg/kg | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors | CNREA8 22,152,1962 |
intramuscular/rat | toxic dose: 90 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Musculoskeletal: Tumors Tumorigenic: Tumors at site of application | CNREA8 22,158,1962 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intramuscular/mouse | lowest published lethal dose: 400 mg/kg | CNREA8 22,152,1962 | |
intratracheal/rat | lowest published lethal dose: 50 mg/kg | VCVN5* -,452,1989 | |
intratracheal/rat | lowest published toxic dose: 25 mg/kg | Lung, Thorax, or Respiration: Emphysema Lung, Thorax, or Respiration: Fibrosis (interstitial) Lung, Thorax, or Respiration: Fibrosing alveolitis | VCVN5* -,452,1989 |
oral/Dog | lowest published lethal dose: 89 mg/kg | EQSSDX 1,1,1975 | |
oral/rat | lethal dose (50 percent kill): 202 mg/kg | Behavioral: Somnolence (general depressed activity) Gastrointestinal: Hypermotility, diarrhea Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FCTOD7 20,311,1982 |
oral/rat | lethal dose (50 percent kill): 202 mg/kg | Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Blood: Hemorrhage | VCVN5* -,453,1989 |
subcutaneous/mouse | lethal dose (50 percent kill): 125 mg/kg | ZVKOA6 19,186,1974 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/guinea pig | lowest published toxic dose: 50 mg/m3/8H/35D- intermittent | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** OTS0555434 |
inhalation/rabbit | lowest published toxic concentration: 50 mg/m3/8H/35D- intermittent | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** OTS0555434 |
inhalation/rat | lowest published toxic concentration: 50 mg/m3/8H/19D- intermittent | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** OTS0555434 |
oral/rat | lowest published toxic dose: 783 mg/kg/90D- continuous | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0555434 |
subcutaneous/mouse | lowest published toxic dose: 125 mg/kg/5D- intermittent | Behavioral: Tetany Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,458,1989 |
subcutaneous/rat | lowest published toxic dose: 100 mg/kg/5D- intermittent | Behavioral: Somnolence (general depressed activity) Behavioral: Food intake (animal) | VCVN5* -,458,1989 |
subcutaneous/rat | lowest published toxic dose: 300 mg/kg/15D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN5* -,458,1989 |
subcutaneous/rat | lowest published toxic dose: 1144 mg/kg/9W- intermittent | Lung, Thorax, or Respiration: Changes in lung weight Endocrine: Changes in adrenal weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | GISAAA 26(10),27,1961 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.02 mg(Co)/m3 | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 52,363,1991 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 52,363,1991 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 52,363,1991 |
TOXICOLOGY REVIEW | FCTXAV 9,105,1971 |
Standards and Regulations
NIOSH Documentation and Surveillance
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division