Registry of Toxic Effects of Chemical Substances (RTECS)
Nitric acid
RTECS #
QU5775000CAS #
7697-37-2Updated
September 201Molecular Weight
63.02Molecular Formula
HNO3Synonyms
Acide nitrique (French)Acido nitrico (Italian)
Aqua fortis
Azotic acid
Azotowy kwas (Polish)
Hydrogen nitrate
Kyselina dusicne (Czech)
Nitric acid (ACGIH:OSHA)
Salpetersaure (German)
Salpeterzuuroplossingen (Dutch)
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | 21150 mg/kg (1-21D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | ZHYGAM 29,667,1983 |
oral/rat | 2345 mg/kg (18D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic | ZHYGAM 29,667,1983 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 40 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
inhalation/cat | lowest published toxic concentration: 300 mg/m3/2H | Lung, Thorax, or Respiration: Acute pulmonary edema | VCVN5* -,45,1993 |
inhalation/cat | Lowest published lethal concentration: 500 mg/m3 | VCVN5* -,45,1993 | |
inhalation/rat | lethal concentration (50 percent kill): 260 mg/m3/30M | VCVN5* -,45,1993 | |
inhalation/rat | lethal concentration (50 percent kill): 130 mg/m3/4H | VCVN5* -,45,1993 | |
inhalation/rat | lowest published toxic concentration: 460 ppm/1H | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 44,302,2005 |
inhalation/rat | Lowest published lethal concentration: 919 ppm/1H | TOXID9 44,302,2005 | |
oral/human | lowest published lethal dose: 430 mg/kg | YAKUD5 22,651,1980 | |
skin/rat | lowest published toxic dose: 150 mL/kg | Blood: Methemoglobinemia- Carboxhemoglobinemia | VCVN5* -,46,1993 |
unreported route/man | lowest published lethal dose: 110 mg/kg | 85DCAI 2,73,1970 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | lowest published toxic concentration: 1071 µg/m3/24H/84D- continuous | Behavioral: Muscle contraction or spasticity Kidney, Ureter, and Bladder: Other changes in urine composition Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | GISAAA 38(3),6,1973 |
inhalation/rat | lowest published toxic concentration: 50 µg/m3/4H/3D- intermittent | Lung, Thorax, or Respiration: Respiratory depression | INHTE5 8,595,1996 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2 ppm;short term exposure limit 4 ppm | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | ANAEA3 35,165,1975 | |
TOXICOLOGY REVIEW | ARTODN 39,299,1978 | |
TOXICOLOGY REVIEW | NCLNA* 16,107,1998 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 2 ppm (5 mg/m3) | DTLVS* 3,181,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 2 ppm (5 mg/m3), JAN1993 | |
Occupational Exposure Limit-AUSTRALIA | time-weighted average 2 ppm (5.2 mg/m3), short term exposure limit 4 ppm (10 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-KZW 1 ppm (2.6 mg/m3), 2007 | |
Occupational Exposure Limit-BELGIUM | short term exposure limit 1 ppm (2.6 mg/m3), MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 1 ppm (2.6 mg/m3), MAY2011 | |
Occupational Exposure Limit-EC | short term exposure limit 2.6 mg/m3 (1 ppm), FEB2006 | |
Occupational Exposure Limit-FINLAND | time-weighted average 0.5 ppm (1.3 mg/m3), short term exposure limit 1 ppm (2.6 mg/m3), NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 2 ppm (5 mg/m3), VLE 4 ppm (10 mg/m3), FEB2006 | |
Occupational Exposure Limit-HUNGARY | time-weighted average 5 mg/m3, short term exposure limit 5 mg/m3, SEP2000 | |
Occupational Exposure Limit-ICELAND | short term exposure limit 1 ppm (2.6 mg/m3), NOV2011 | |
Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 2 ppm (5.2 mg/m3), MAY2012 | |
Occupational Exposure Limit-KOREA | time-weighted average 2 ppm (5 mg/m3), short term exposure limit 4 ppm (10 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 2 ppm (5 mg/m3);short term exposure limit 4 ppm (10 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 2 ppm (5.2 mg/m3), short term exposure limit 4 ppm (10 mg/m3), JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 2 ppm (5 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 2 ppm (5.2 mg/m3); short term exposure limit 4 ppm (10.4 mg/m3), JUL2005 | |
Occupational Exposure Limit-POLAND | MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 2 mg/m3, Skin, JUN2003 | |
Occupational Exposure Limit-SWEDEN | time-weighted average 2 ppm (5 mg/m3);short term exposure limit 5 ppm (13 mg/m3), JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | ceiling concentration 2 ppm (5 mg/m3), JAN2011 | |
Occupational Exposure Limit-THAILAND | time-weighted average 2 ppm (5 mg/m3), JAN1993 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 2 ppm (5 mg/m3), JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 2 ppm (5 mg/m3), JAN1993 | |
Occupational Exposure Limit-UNITED KINGDOM | short term exposure limit 1 ppm (2.6 mg/m3), OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 2 ppm (5 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 2 ppm (5 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 2 ppm (5 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 2 ppm (5 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NITRIC ACID-air | 10H time-weighted average 2 ppm;short term exposure limit 4 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 50742; Number of Industries 201; Total Number of Facilities 18239; Number of Occupations 120; Total Number of Employees Exposed 297627; Total Number of Female Employees Exposed 76316 | |
National Occupational Hazard Survey 1974 | Hazard Code 50742; Number of Industries 197; Total Number of Facilities 18088; Number of Occupations 101; Total Number of Employees Exposed 132401 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division