p-Nitroaniline

CAS number: 100–01–6

NIOSH REL: 3 mg/m³ TWA [skin]

Current OSHA PEL: 6 mg/m³ (1 ppm) TWA [skin]

1989 OSHA PEL: 3 mg/m³ TWA [skin]

1993-1994 ACGIH TLV: 3 mg/m³ TWA [skin]

Description of substance: Bright yellow, crystalline powder with a slight ammonia-like odor.

LEL: . . . Unknown

Original (SCP) IDLH: 300 mg/m³

Basis for original (SCP) IDLH: The chosen IDLH (300 mg/m³ or 50 ppm) is based on an analogy with aniline and the statement by AIHA [1955] that 50 to 100 ppm aniline can probably be tolerated for 1 hour. Although the IDLH chosen for aniline was 100 ppm, the IDLH of 50 ppm (300 mg/m³) chosen for p-nitroaniline is reasonable because Von Oettingen [1941] stated that p-nitroaniline is more toxic than aniline.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal dose data:

Species	Reference	Route	LD50 (mg/kg)	LDLo (mg/kg)	Adjusted LD	Derived value
Rat Rat G. pig Mouse	Back et al. 1972 Matrka et al. 1978 Moskalenko 1966 Vernot et al. 1977	oral oral oral oral	3,249 750 450 810	----- ----- ----- -----	22,743 mg/m3 5,250 mg/m3 3,150 mg/m3 5,670 mg/m3	2,274 mg/m3 525 mg/m3 315 mg/m3 567 mg/m3

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 300 mg/m3 [Unchanged] Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for p-nitroaniline. Therefore, based on acute oral toxicity data in animals [Matrka et al. 1978; Moskalenko 1966; Vernot et al. 1977], the original IDLH for p-nitroaniline (300 mg/m3) is not being revised at this time.

REFERENCES:

1. AIHA [1955]. Aniline. In: Hygienic guide series. Am Ind Hyg Assoc Q 16:331-332.

2 Back KC, Thomas AA, MacEwen JD [1972]. Reclassification of materials listed as transportation health hazards. Wright-Patterson Air Force Base, OH: 6570th Aerospace Medical Research Laboratory, Report No. TSA-20-72-3, pp. A-298 to A-299.

3. Matrka M, Rambousek V, Zverina Z [1978]. Toxicity of p-substituted derivatives of aniline in experimental rats. Ceskoslovenska Hygiena (Czechoslovak Hygiene) 23:168-172 (in Czechoslovakian).

4. Moskalenko EG [1966]. Toxicological characteristics of nitroanilines. Vop Komm Gig 6:89-94 (in Russian).

5. Vernot EH, MacEwen JD, Haun CC, Kinkead FR [1977]. Acute toxicity and skin corrosion data for some organic and inorganic compounds and aqueous solutions. Toxicol Appl Pharmacol 42:417-423.

6. von Oettingen WF [1941]. The aromatic amino and nitro compounds, their toxicity and potential dangers. Public Health Bulletin 271:34.