Ethyl butyl ketone

CAS number: 106–35–4

NIOSH REL: 50 ppm (230 mg/m³) TWA

Current OSHA PEL: 50 ppm (230 mg/m³) TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 50 ppm (234 mg/m³) TWA

Description of Substance: Colorless liquid with a powerful, fruity odor.

LEL:. . Unknown

Original (SCP) IDLH: 3,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statements by Patty [1963] and Deichmann and Gerarde [1969] that 0 rats died following a 4-hour exposure to 2,000 ppm, but 6 of 6 rats died following a 4-hour exposure to 4,000 ppm [Smyth et al. 1949].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species	Reference	LC50 (ppm)	LCLo (ppm)	Time	Adjusted 0.5-hr LC (CF)	Derived value
Rat	Smyth et al. 1949	LC100: 4,000	-----	4 hr	8,000 ppm (2.0)	800 ppm

Lethal dose data:

Species	Reference	Route	LD50 (mg/kg)	LDLo (mg/kg)	Adjusted LD	Derived value
Rat	Smyth et al. 1949	oral	2,760	-----	4,067 ppm	408 ppm

Other animal data: It has been reported that rats survived a 4-hour exposure to 2,000 ppm [Smyth et al. 1949].

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 1,000 ppm Basis for revised IDLH: The revised IDLH for ethyl butyl ketone is 1,000 ppm based on acute inhalation toxicity data in animals [Smyth et al. 1949].

REFERENCE:

1. Deichmann WB, Gerarde HW [1969]. Table 50. Toxicity of ketones. In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., p. 736.

2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1741.

3. Smyth HF Jr, Carpenter CP, Weil CS [1949]. Range-finding toxicity data: list III. J Ind Hyg Toxicol 31:60-62.