n-Propyl acetate

CAS number: 109–60–4

NIOSH REL: 200 ppm (840 mg/m³) TWA, 250 ppm (1,050 mg/m³) STEL

Current OSHA PEL: 200 ppm (840 mg/m³) TWA

1989 OSHA PEL: 200 ppm (840 mg/m³) TWA, 250 ppm (1,050 mg/m³) STEL

1993-1994 ACGIH TLV: 200 ppm (835 mg/m³) TWA, 250 ppm (1,040 mg/m³) STEL

Description of substance: Colorless liquid with a mild, fruity odor.

LEL(@100°F): 1.7% (10% LEL(@100°F), 1,700 ppm)

Original (SCP) IDLH: 8,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that a 4-hour exposure to 8,000 ppm was fatal to 4 of 6 rats [Smyth et al. 1954].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

Species	Reference	LC50 (ppm)	LCLo (ppm)	Time	Adjusted 0.5-hr LC (CF)	Derived value
Cat	Flury & Wirth 1933	-----	8,941	5 hr	19,223 ppm (2.15)	1,922 ppm
Rat	Smyth et al. 1969	LC67: 8,000	-----	4 hr	16,000 ppm (2.0)	1,600 ppm

Lethal dose data:

Species	Reference	Route	LD50 (mg/kg)	LDLo (mg/kg)	Adjusted LD	Derived value
Rat Mouse Rabbit Rat	Jenner et al. 1964 Jenner et al. 1964 Munch 1972 Smyth et al. 1969	oral oral oral oral	9,370 8,300 6,640 8,700	----- ----- ----- -----	15,433 ppm 13,671 ppm 10,936 ppm 14,329 ppm	1,543 ppm 1,367 ppm 1,094 ppm 1,433 ppm

Other animal data: It has been reported that based on acute inhalation studies, n-propyl acetate appears to be more toxic than isopropyl acetate and ethyl acetate but less toxic than n-butyl acetate [ACGIH 1991].

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 1,700 ppm Basis for revised IDLH: The revised IDLH for n-propyl acetate is 1,700 ppm based on acute inhalation toxicity data in animals [Flury and Wirth 1933; Smyth et al. 1969]. The revised IDLH is roughly the same as the revised IDLHs for ethyl acetate and n-butyl acetate and is also 10% of the lower explosive limit of 1.7% (which was determined at 100°F). This may be a conservative value due to the lack of relevant acute inhalation toxicity data for workers.

REFERENCES:

1. ACGIH [1971]. n-Propyl acetate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 216.

2. ACGIH [1991]. n-Propyl acetate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 1300.

3. Flury F, Wirth W [1933]. Zur toxikologie der lösungsmittel. (Verschieden ester, aceton, methylalkohol.) Arch Gewerbepath Gewerbehyg 5:1-90 (in German).

4. Jenner PM, Hagan EC, Taylor JM, Cook EL, Fitzhugh OG [1964]. Food flavourings and compounds of related structure. I. Acute oral toxicity. Food Cosmet Toxicol 2:327-343.

5. Munch JC [1972]. Aliphatic alcohols and alkyl esters: narcotic and lethal potencies to tadpoles and to rabbits. Ind Med Surg 41:31-33.

6. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med 10:61-68.

7. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA, Nycum JS [1969]. Range-finding toxicity data: list VII. Am Ind Hyg Assoc J 30(5):470-476.