Tributyl phosphate

CAS number: 126–73–8

NIOSH REL: 0.2 ppm (2.5 mg/m³) TWA

Current OSHA PEL: 5 mg/m³ TWA

1989 OSHA PEL: 0.2 ppm (2.5 mg/m³) TWA

1993-1994 ACGIH TLV: 0.2 ppm (2.2 mg/m³) TWA

Description of substance: Colorless to pale-yellow, odorless liquid.

LEL: . . Unknown

Original (SCP) IDLH: 125 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the only available data on acute inhalation toxicity of exposure to tributyl phosphate. Patty [1963] reported that 0 of 3 rats succumbed to a 6-hour exposure to 123 ppm (1,337 mg/m³) [Fassett]. No other quantitative data are available on which to base the IDLH.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

Species	Reference	LC50 (ppm)	LCLo (ppm)	Time	Adjusted 0.5-hr LC (CF)	Derived value
Cat	Eller 1937	-----	2,214	5 hr	4,760 ppm (2.15)	476 ppm
Cat	IPCS 1991	227	-----	4-5 hr	454-488 ppm (2.0/2.15)	45-49 ppm
Rat	IPCS 1991	123	-----	6 hr	283 ppm (2.3)	28 ppm
Rat	Kalinina 1971	117	-----	?	?	?
Rat	TSCATS	2,529	-----	1 hr	3,161 ppm (1.25)	316 ppm

Lethal dose data:

Species	Reference	Route	LD50 (mg/kg)	LDLo (mg/kg)	Adjusted LD	Derived value
Mouse	Kalinina 1971	oral	1,189	-----	752 ppm	75 ppm
Rat	Smyth & Carpenter 1944	oral	3,000	-----	1,897 ppm	190 ppm

Other animal data: It has been reported that rats survived a 6-hour exposure to 123 ppm (1,337 mg/m³) [Patty 1963].

Human data: Nausea and headache have been reported in workers exposed to 15 mg/m³ (1.4 ppm) [Mastromatteo 1964].

Revised IDLH: 30 ppm Basis for revised IDLH: The revised IDLH for tributyl phosphate is 30 ppm based on acute inhalation toxicity data in animals [IPCS 1991]. This may be a conservative value due to the lack of relevant acute toxicity data in humans exposed to concentrations above 1.4 ppm.

REFERENCES:

1. ACGIH [1991]. Tributyl phosphate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1600-1601.

2. Eller H [1937]. Beitrag zur toxikologie technischer weichmachungsmittel (dissertation). Pharmakologishen Institut der Universitat Wursburg, Germany.

3. Fassett DW [?]. Unpublished data from the Laboratory of Industrial Medicine, Eastman Kodak Company, Rochester, NY. [From Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1915.]

4. IPCS [1991]. Environmental health criteria 112, tri-n-butyl phosphate. Geneva, Switzerland: World health Organization, International Programme on Chemical Safety. [From ACGIH [1991]. Tributyl phosphate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1600-1601.]

5. Kalinina NI [1971]. Toxicity of phosphoroorganic platificators tributyl phosphate and di(2-ethylhexyl)phenyl phosphate. Gig Tr Prof Zabol 15(8):30-33 (in Russian).

6. Mastromatteo E [1964]. Personal communication to TLV Committee. [From ACGIH [1991]. Tributyl phosphate. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1600-1601.]

7. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1915.

8. Smyth HF Jr, Carpenter CP [1944]. The place of the range-finding test in the industrial toxicology laboratory. J Ind Hyg Toxicol 26:269-273.

9. TSCATS. Office of Toxic Substances Report FYI-OTS-0285-0380.