Dimethyl acetamide

CAS number: 127–19–5

NIOSH REL: 10 ppm (35 mg/m³) TWA [skin]

Current OSHA PEL: 10 ppm (35 mg/m³) TWA [skin]

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 10 ppm (36 mg/m³) TWA [skin]

Description of Substance: Colorless liquid with a weak, ammonia- or fish-like odor.

LEL(@212 F): 1.8% (10% LEL(@212 F), 1,800 ppm)

Original (SCP) IDLH: 400 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by Deichmann and Gerarde [1969] that acute inhalation at 406 and 575 ppm causes some deaths and degeneration of the liver in several species of laboratory animals. Although no time period is specified for that exposure, the chosen IDLH is probably reasonable, and perhaps even conservative, because Patty [1963] reported that liver injury was noted only in some rats and dogs exposed to repeated inhalation at 100 to 200 ppm [Horn].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species	Reference	LC50 (ppm)	LCLo (ppm)	Time	Adjusted 0.5-hr LC (CF)	Derived value
Rat	Kennedy and Sherman 1986	2,475	-----	1 hr	2,970 ppm (1.2)	297 ppm

Lethal dose data:

Species	Reference	Route	LD50 (mg/kg)	LDLo (mg/kg)	Adjusted LD	Derived value
Mouse Rat	Bartsch et al. 1976 Monsanto 1990	oral oral	4,620 4,800	----- -----	8,934 ppm 9,282 ppm	893 ppm 928 ppm

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 300 ppm Basis for revised IDLH: The revised IDLH for dimethyl acetamide is 300 ppm based on acute inhalation toxicity data in animals [Kennedy and Sherman 1986].

REFERENCES:

1. Bartsch W, Sponer G, Dietmann K, Fuchs G [1976]. Acute toxicity of various solvents in the mouse and rat. Arzneimittel-Forschung (Drug Research) 26(8):1581-1583 (in German).

2. Deichmann WB, Gerarde HW [1969]. Dimethylacetamide (DMA). In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., p. 655.

3. Horn HJ [?]. Personal communication. [From Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1834.]

4. Kennedy GL, Sherman H [1986]. Acute and subchronic toxicity of dimethylformamide and dimethylacetamide following various routes of administration. Drug Chem Toxicol 9(2):147-170.

5. Monsanto [1990]. 8EHQ-0590-0981 submission on DMF/DMAC to U.S. EPA. St. Louis, MO: Monsanto Chemical Company. United States Environmental Protection Agency, Office of Pesticides and Toxic Substances.

6. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1834.