Ethyl acrylate

CAS number: 140–88–5

NIOSH REL: None established; NIOSH considers ethyl acrylate to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].

Current OSHA PEL: 25 ppm (100 mg/m³) TWA [skin]

1989 OSHA PEL: 5 ppm (20 mg/m³) TWA, 25 ppm (100 mg/m³) STEL [skin]

1993-1994 ACGIH TLV: 5 ppm (20 mg/m³) TWA, 15 ppm (61 mg/m³) STEL, A2

Description of Substance: Colorless liquid with an acrid odor.

LEL:. . 1.4% (10% LEL, 1,400 ppm)

Original (SCP) IDLH: 2,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statements by Pozzani et al. 1949 cited by Patty [1963], and UCC [1971] that 5 of 6 rats died following a 4-hour exposure to 2,000 ppm, and that 1,000 ppm for 4 hours killed 0 of 6 rats.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species	Reference	LC50 (ppm)	LCLo (ppm)	Time	Adjusted 0.5-hr LC (CF)	Derived value
Rat Rabbit G. pig Rat Mouse	Oberly and Tansy 1985 Pozzani et al. 1949 Pozzani et al. 1949 Pozzani et al. 1949 Sidorov and Timofievskaya 1979	2,180 ----- ----- LC83: 2,000 3,894	----- 1,204 1,204 ----- -----	4 hr 7 hr 7 hr 4 hr ?	4,360 ppm (2.0) 2,890 ppm (2.4) 2,890 ppm (2.4) 4,000 ppm (2.0) ?	436 ppm 289 ppm 289 ppm 400 ppm ?

Other animal data: RD₅₀ (mouse), 315 ppm [DeCeaurriz et al. 1981]. Thirty-day exposures of rats to 300 or 540 ppm resulted in mortality; while rats survived 30-day exposures to 70 ppm [Treon et al. 1949].

Human data: Prolonged inhalation exposures at 50 to 75 ppm produced drowsiness, headache, and nausea [Nemec and Bauer 1978].

Revised IDLH: 300 ppm Basis for revised IDLH: The revised IDLH for ethyl acrylate is 300 ppm based on toxicity data in humans [Nemec and Bauer 1978] and animals [DeCeaurriz et al. 1981; Oberly and Tansy 1985; Pozzani et al. 1949; Treon et al. 1949]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for ethyl acrylate at any detectable concentration.]

REFERENCES:

1. DeCeaurriz JC, Micillino JC, Bonnet P, Guenier JP [1981]. Sensory irritation caused by various industrial airborne chemicals. Toxicol Lett 9(4):137-143.

2. Nemec JW, Bauer W Jr [1978]. Acrylic acid and deviations. In: Encyclopedia of Chemical Toxicology. Vol. I. 3rd ed. New York, NY: John Wiley & Sons, pp. 330-354.

3. Oberly R, Tansy MF [1985]. LC50 values for rats acutely exposed to vapors of acrylic and methacrylic acid esters. J Toxicol Environ Health 16:811-822.

4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1880.

5. Pozzani U, Weil CS, Carpenter CP [1949]. Subacute vapor toxicity and range-finding data for ethyl acrylate. J Ind Hyg Toxicol 31:311-316.

6. Sidorov KK, Timofievskaya LA [1979]. Data for use in salting the UAC for monoethanolamine in the working environment. Gig Tr Prof Zabol 23(9):55 (in Russian).

7. Treon JF, Sigmon H, Wright H, Kitzmiller KV [1949]. The toxicity of methyl and ethyl acrylate. J Ind Hyg Toxicol 31:317-326.

8. UCC [1971]. Toxicology studies: ethyl acrylate. New York, NY: Union Carbide Corporation.