Ronnel

CAS number: 299–84–3

NIOSH REL: 10 mg/m³ TWA

Current OSHA PEL: 15 mg/m³ TWA

1989 OSHA PEL: 10 mg/m³ TWA

1993-1994 ACGIH TLV: 10 mg/m³ TWA

Description of substance: White to light-tan, crystalline solid.

LEL:. . Noncombustible Solid

Original (SCP) IDLH: 5,000 mg/m³

Basis for original (SCP) IDLH: No useful data on acute inhalation toxicity are available on which to base the IDLH for ronnel. The chosen IDLH, therefore, has been estimated from the statement by ACGIH [1971] that the dog oral LD₅₀ is greater than 500 mg/kg.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal dose data:

Species	Reference	Route	LD50 (mg/kg)	LDLo (mg/kg)	Adjusted LD	Derived value
Mouse Rabbit G. pig Dog Rat	AAPCO 1966 AAPCO 1966 AAPCO 1966 Klimmer 1971 Gig Sanit 1990	oral oral oral oral oral	2,000 420 1,400 500 625	----- ----- ----- ----- -----	7,000 mg/m3 2,940 mg/m3 9,800 mg/m3 3,500 mg/m3 4,375 mg/m3	700 mg/m3 294 mg/m3 980 mg/m3 350 mg/m3 438 mg/m3

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 300 mg/m3 Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for ronnel. Therefore, the revised IDLH for ronnel is 300 mg/m3 based on acute oral toxicity in animals [AAPCO 1966; Klimmer 1971]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.

REFERENCES:

1. AAPCO [1966]. Pesticide chemicals official compendium. Topeka, KS: Association of American Pesticide Control Officials, Inc., p. 965.

2. ACGIH [1971]. Ronnel. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 222.

3. Klimmer OR [1971]. Pflanzenschutz-und schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen. 2nd ed. Hattingen, Germany: Hundt-Verlag, p. 26.

4. Gig Sanit [1990]. Long-term effects from transformation products of pesticides and surfactants; 45(6):14-17 (in Russian).