Tetramethyl succinonitrile

CAS number: 3333–52–6

NIOSH REL: 3 mg/m³ (0.5 ppm) TWA [skin]

Current OSHA PEL: 3 mg/m³ (0.5 ppm) TWA [skin]

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 2.8 mg/m³ (0.5 ppm) TWA [skin]

Description of substance: Colorless, odorless solid.

LEL: . Unknown

Original (SCP) IDLH: 5 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1972] that 6 ppm for 30 hours was lethal to rats [Spolyar 1948]. A concentration of 22 ppm is obviously too high to be chosen as the IDLH, because no mice survived a 3.5-hour exposure at this concentration [Hecht and Kimmerle 1956-1957 as quoted by Reinl 1957].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

Species	Reference	LC50 (ppm)	LCLo (ppm)	Time	Adjusted 0.5-hr LC (CF)	Derived value
Mouse	Hecht &Kimmerle 1956/1957	-----	28	3 hr	50 ppm (1.8)	5.0 ppm
Mouse	Hecht &Kimmerle 1956/1957	LC100: 22	-----	3.5 hr	42 ppm (1.9)	4.2 ppm
Rat	Spolyar 1948	-----	6	30 hr	24 ppm (3.91)	2.4 ppm

Lethal dose data:

Species	Reference	Route	LD50 (mg/kg)	LDLo (mg/kg)	Adjusted LD	Derived value
Rat	Johannsen &ivinskas 1986	oral	38.9	-----	48 ppm	4.8 ppm

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 5 ppm [Unchanged] Basis for revised IDLH: Based on acute inhalation toxicity data in animals [Hecht and Kimmerle 1956-1957], the original IDLH for tetramethyl succinonitrile (5 ppm) is not being revised at this time.

REFERENCES:

1. ACGIH [1972]. Tetramethyl succinonitrile. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 254.

2. Harger RN, Hupieu HR [1949]. Toxicity of tetramethyl succinonitrile and the antidotal effects of thiosulphate, nitrile, and barbiturates. Fed Proc 8:205.

3. Hecht G, Kimmerle H [1956/1957]. Toxikologische Untersuchungen uber Tetramethyl-bernsteinsauredinitril. Unpublished investigations (in German). [From Reinl W [1957]. Intoxication in manufacturing of plastics by tetramethyl-succinic acid dinitrile. Arch Toxikol 16:367-380 (in German).]

4. Johannsen FR, Livinskas GJ [1986]. Subchronic toxicity of tetramethyl succinonitrile. Fundam Appl Toxicol 7:41-48.

5. Reinl W [1957]. Intoxication in manufacturing of plastics by tetramethyl-succinic acid dinitrile. Arch Toxikol 16:367-380 (in German).

6. Spolyar LW [1948]. Indiana chemists report toxicity of product of Porofor M. Ind Hyg Newsletter 8(10)3.