Isopropyl glycidyl ether

CAS number: 4016–14–2

NIOSH REL: 50 ppm (240 mg/m³) 15-minute CEILING

Current OSHA PEL: 50 ppm (240 mg/m³) TWA

1989 OSHA PEL: 50 ppm (240 mg/m³) TWA, 75 ppm (360 mg/m³) STEL

1993-1994 ACGIH TLV: 50 ppm (238 mg/m³) TWA, 75 ppm (356 mg/m³) STEL

Description of substance: Colorless liquid.

LEL: . . Unknown

Original (SCP) IDLH: 1,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse 4-hour LC₅₀ of 1,500 ppm and the rat 8-hour LC₅₀ of 1,100 ppm [Hine et al. 1956 cited by Patty 1963].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

Species	Reference	LC50 (ppm)	LCLo (ppm)	Time	Adjusted 0.5-hr LC (CF)	Derived value
Mouse Rat	Hine et al. 1956 Hine et al. 1956	1,500 1,100	----- -----	4 hr 8 hr	3,000 ppm (2.0) 2,750 ppm (2.5)	300 ppm 275 ppm

Human data: Workers exposed to 400 ppm have suffered irritation of the eyes and respiratory tract [Hine et al. 1956].

Revised IDLH: 400 ppm Basis for revised IDLH: The revised IDLH for isopropyl glycidyl ether is 400 ppm based on acute inhalation toxicity data in workers [Hine et al. 1956]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 400 ppm.

REFERENCES:

1. Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health 14:250-264.

2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1638.