Glycidol

CAS number: 556–52–5

NIOSH REL: 25 ppm (75 mg/m³) TWA

Current OSHA PEL: 50 ppm (150 mg/m³) TWA

1989 OSHA PEL: 25 ppm (75 mg/m³) TWA

1993-1994 ACGIH TLV: 25 ppm (76 mg/m³) TWA

Description of Substance: Colorless liquid.

LEL: . . Unknown

Original (SCP) IDLH: 500 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse 4-hour LC₅₀ of 450 ppm and the rat 8-hour LC₅₀ of 580 ppm [Hine et al. 1956 cited by ACGIH 1971, and Patty 1963].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species	Reference	LC50 (ppm)	LCLo (ppm)	Time	Adjusted 0.5-hr LC (CF)	Derived value
Mouse Rat	Hine et al. 1956 Hine et al. 1956	450 580	----- -----	4 hr 8 hr	900 ppm (2.0) 1,450 ppm (2.5)	90 ppm 145 ppm

Other animal data: It has been reported that rats exposed repeatedly to 400 ppm for 7 hours per day, 5 days a week for 10 weeks showed no evidence of cumulative toxicity, only very slight irritation of the eyes, and slight lacrimation and respiratory distress following the first few exposures [Hine et al. 1956].

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 150 ppm Basis for revised IDLH: The revised IDLH for glycidol is 150 ppm based on acute inhalation toxicity data in animals [Hine et al. 1956].

REFERENCES:

1. ACGIH [1971]. Glycidol. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 121-122.

2. Hine CH, Kodama JS, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health 14:250-264.

3. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1635.