1,1-Dichloro-1-nitroethane

CAS number: 594–72–9

NIOSH REL: 2 ppm (10 mg/m³) TWA

Current OSHA PEL: 10 ppm (60 mg/m³) CEILING

1989 OSHA PEL: 2 ppm (10 mg/m³) TWA

1993-1994 ACGIH TLV: 2 ppm (12 mg/m³) TWA

Description of Substance: Colorless liquid with an unpleasant odor.

LEL:. . Unknown

Original (SCP) IDLH: 150 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the study by Machle et al. [1945] in which autopsies on animals exposed to over 170 ppm for over 30 minutes revealed pulmonary edema and hemorrhage, with damage to the heart, liver, and kidneys.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species	Reference	LC50 (ppm)	LCLo (ppm)	Time	Adjusted 0.5-hr LC (CF)	Derived value
Rabbit G. pig Rabbit G. pig Rabbit G. pig	Machle et al. 1945 Machle et al. 1945 Machle et al. 1945 Machle et al. 1945 Machle et al. 1945 Machle et al. 1945	170 170 97 97 52 52	----- ----- ----- ----- ----- -----	30 min 30 min 6 hr 6 hr 18.75 hr 18.75 hr	170 ppm (1.0) 170 ppm (1.0) 223 ppm (2.3) 223 ppm (2.3) 172 ppm (3.33) 172 ppm (3.33)	17 ppm 17 ppm 22 ppm 22 ppm 17 ppm 17 ppm

Other animal data: Animals have tolerated 25 ppm for 204 hours [ Machle et al. 1945].

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 25 ppm Basis for revised IDLH: The revised IDLH for 1,1-dichloro-1-nitroethane is 25 ppm based on acute inhalation toxicity data in animals [Machle et al. 1945]. This may be a conservative value due to the lack of relevant acute toxicity data for workers.

REFERENCE:

1. Machle W, Scott EW, Treon JF, Heyroth FF, Kitzmiller KV [1945]. The physiological response of animals to certain chlorinated mononitroparaffins. J Ind Hyg Toxicol 27(4):95-102.