1-Chloro-1-nitropropane

CAS number: 600–25–9

NIOSH REL: 2 ppm (10 mg/m³) TWA

Current OSHA PEL: 20 ppm (100 mg/m³) TWA

1989 OSHA PEL: 2 ppm (10 mg/m³) TWA

1993-1994 ACGIH TLV: 2 ppm (10 mg/m³) TWA

Description of Substance: Colorless liquid with an unpleasant odor.

LEL: . . Unknown

Original (SCP) IDLH: 2,000 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement in Patty [1963] that 1 of 2 guinea pigs died following a 1-hour exposure to 2,178 ppm; no rabbits died from this exposure, and no rabbits or guinea pigs died from a 1-hour exposure to 1,069 ppm [Machle et al. 1945].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species	Reference	LC50 (ppm)	LCLo (ppm)	Time	Adjusted 0.5-hr LC (CF)	Derived value
G. pig Rabbit Rabbit G. pig Mouse	Machle et al. 1945 Machle et al. 1945 Machle et al. 1945 Machle et al. 1945 Neklesova and Kudrina 1969	2,178 ----- LC100: 2,574 ----- 12,840	----- 389 ----- 3,502 -----	1 hr 6 hr 6 hr 2 hr 3 hr	2,723 ppm (1.25) 895 ppm (2.3) 5,920 ppm (2.3) 5,603 ppm (1.6) 23,112 ppm (1.8)	272 ppm 90 ppm 592 ppm 560 ppm 2,311 ppm

Lethal dose data:

Species	Reference	Route	LD50 (mg/kg)	LDLo (mg/kg)	Adjusted LD	Derived value
Rabbit Rat Mouse	Machle et al. 1945 Marhold 1986 Neklesova and Kudrina 1969	oral oral oral	----- ----- 510	50 50 -----	68 ppm 68 ppm 695 ppm	6.8 ppm 6.8 ppm 70 ppm

Human data None relevant for use in determining the revised IDLH.

Revised IDLH: 100 ppm Basis for revised IDLH: The revised IDLH for 1-chloro-1-nitropropane is 100 ppm based on acute inhalation toxicity data in animals [Machle et al. 1945].

REFERENCES:

1. Machle W, Scott EW, Treon JF, Heyroth FF, Kitzmiller KV [1945]. The physiological response of animals to certain chlorinated mononitroparaffins. J Ind Hyg Toxicol 27(4):95-102.

2. Marhold J [1986]. Prehled Prumyslove Toxikologie, Organicke Latky. Prague, Czechoslovakia: Avicenum, p. 596 (in Czechoslovakian).

3. Neklesova ID, Kudrina MA [1969]. Comparative toxicological characteristics of certain chloronitroparaffins. Gig Sanit 34(10-12):429-432 (translated).

4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 2082.