Phosdrin

CAS number: 7786–34–7

NIOSH REL: 0.01 ppm (0.1 mg/m³) TWA, 0.03 ppm (0.3 mg/m³) STEL [skin]

Current OSHA PEL: 0.1 mg/m³ TWA [skin]

1989 OSHA PEL: 0.01 ppm (0.1 mg/m³) TWA, 0.03 ppm (0.3 mg/m³) STEL [skin]

1993-1994 ACGIH TLV: 0.01 ppm (0.92 mg/m³) TWA,

0.03 ppm (0.27 mg/m³) STEL [skin]

Description of substance: Pale-yellow to orange liquid with a weak odor.

LEL: . . Unknown

Original (SCP) IDLH: 4 ppm

Basis for original (SCP) IDLH: No useful data on acute inhalation toxicity are available on which to base the IDLH for Phosdrin. The chosen IDLH has been estimated from the male rat oral LD₅₀ of 6 to 7 mg/kg [Shell 1956 cited by ACGIH 1971]. [Note: A concentration of 4 ppm phosdrin is equivalent to about 40 mg/m³.]

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

Species	Reference	LC50 (ppm)	LCLo (ppm)	Time	Adjusted 0.5-hr LC (CF)	Derived value
Rat	Kodama et al. 1954	14	-----	1 hr	18 ppm (1.25)	1.8 ppm

Lethal dose data:

Species	Reference	Route	LD50 (mg/kg)	LDLo (mg/kg)	Adjusted LD	Derived value
Rat Mouse Rat	Kenaga 1979 Kodama et al. 1954 Shell 1956	oral oral oral	3 4 6-7	----- ----- -----	2.3 ppm 3.0 ppm 4.5-5.3 ppm	0.2 ppm 0.3 ppm 0.5 ppm

Human data: A dose of 2.5 mg/day for 27 days caused a 25% decrease in red blood cell cholinesterase [Rider et al. 1975]. [Note: An oral dose of 2.5 mg/day for 27 days is equivalent to a worker being exposed to about 5 ppm for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]

Revised IDLH: 4 ppm [Unchanged] Basis for revised IDLH: Based on acute toxicity data in humans [Rider et al. 1975], the original IDLH for phosdrin (4 ppm) is not being revised at this time.

REFERENCES:

1. ACGIH [1971]. Phosdrin (mevinphos). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 208.

2. Kenaga EE [1979]. Acute and chronic toxicity of 75 pesticides to various animal species. Down to Earth 35:25-31.

3. Kodama J, Morse MS, Anderson HH, Dunlap MK, Hines CH [1954]. Comparative toxicity of two vinyl-substituted phosphates. AMA Arch Ind Hyg Occup Med 9:45-61.

4. Rider JA, Puletti EJ, Swader JI [1975]. The minimal oral toxicity level for mevinphos in man. Toxicol Appl Pharmacol 32(10):97-100.

5. Shell [1956]. Personal communication to ACGIH from the Shell Chemical Corporation, August 31, 1956. [From ACGIH [1991]. Phosdrin. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 1044-1046.]