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NIOSH

p-NITROPHENOL

ICSC: 0066

4-Nitrophenol
4-Hydroxynitrobenzene
C6H5NO3
Molecular mass: 139.1
ICSC # 0066 		CAS # 100-02-7
RTECS # SM2275000
UN # 1663
EC # 609-015-00-2
November 25, 1998 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Powder, water spray, foam, carbon dioxide.
EXPLOSION Finely dispersed particles form explosive mixtures in air.
Prevent deposition of dust; closed system, dust explosion-proof electrical equipment and lighting.
In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
PREVENT DISPERSION OF DUST! STRICT HYGIENE!

•INHALATION Blue lips or finger nails. Blue skin. Cough. Burning sensation. Confusion. Convulsions. Dizziness. Headache. Nausea. Sore throat. Unconsciousness. Weakness.
Local exhaust or breathing protection.
Fresh air, rest. Refer for medical attention.
•SKIN MAY BE ABSORBED! Redness. (Further see Inhalation).
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
•EYES Redness. Pain.
Safety spectacles , face shield or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION Abdominal pain. Sore throat. Vomiting. (See Inhalation).
Do not eat, drink, or smoke during work.
Rinse mouth. Rest. Refer for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Do NOT let this chemical enter the environment. Personal protection: P2 filter respirator for harmful particles.
Separated from combustible and reducing substances, food and feedstuffs . Well closed.
Do not transport with food and feedstuffs.
Xn symbol
R: 20/21/22-33
S: 2-28
UN Hazard Class: 6.1
UN Packing Group: III
ICSC: 0066 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

p-NITROPHENOL

ICSC: 0066

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PHYSICAL STATE; APPEARANCE:
COLOURLESS TO PALE YELLOW CRYSTALS

PHYSICAL DANGERS:
Dust explosion possible if in powder or granular form, mixed with air.

CHEMICAL DANGERS:
May explode on heating. The substance decomposes on heating producing toxic fumes including nitrogen oxides . Mixtures with potassium hydroxide are explosive.

OCCUPATIONAL EXPOSURE LIMITS:
TLV not established.


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

INHALATION RISK:
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is irritating to the eyes, the skin and the respiratory tract . Yellow staining of the skin. The substance may cause effects on the blood , resulting in formation of methaemoglobin. The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact may cause skin sensitization.

PHYSICAL
PROPERTIES

Boiling point (decomposes): 279°C
Melting point: 111-116°C
Density: 1.5
g/cm3
Solubility in water, g/100 ml at 20°C: 1.24
Vapour pressure, Pa at 20°C: 0.0032
Flash point: 169°C
Auto-ignition temperature: 490°C
Octanol/water partition coefficient as log Pow: 1.91

ENVIRONMENTAL
DATA

The substance is toxic to aquatic organisms.

N O T E S

Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Card has been partly updated in April 2005. See section Physical properties.
Transport Emergency Card: TEC (R)-61S1663

NFPA Code: H3; F1; R2;

ADDITIONAL INFORMATION



ICSC: 0066 p-NITROPHENOL
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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