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NIOSH

DIMETHYL SULFATE

ICSC: 0148

Sulfuric acid dimethyl ester
Dimethyl monosulfate
DMS
C2H6O4S / (CH3O)2SO2
Molecular mass: 126.1
ICSC # 0148 		CAS # 77-78-1
RTECS # WS8225000
UN # 1595
EC # 016-023-00-4
November 12, 2008 Validated
Pu, hed in Series 2.

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames. with flammable substances. - deselected by chem. group;
Powder , foam , carbon dioxide , water spray. 9000
EXPLOSION Above 83°C explosive vapour/air mixtures may be formed. 0
Above 83°C use a closed system, ventilation.
fire: cool drums, etc., by spraying with water but avoid contact of the substance with water. - deselected by chem. group; does not apply according to compiler's manual; 15309000
EXPOSURE
AVOID ALL CONTACT!
IN ALL CASES CONSULT A DOCTOR!
•INHALATION Cough. Sore throat. Burning sensation. Shortness of breath. Headache. Symptoms may be delayed (see Notes).
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.
•SKIN MAY BE ABSORBED! Redness. Pain. Blisters. Skin burns.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention. e), Added at update 2007;
•EYES Redness. Pain. Burns. Permanent loss of vision. m Severe deep burns. at update 2007; sible loss of vision has been reported), added at update 2007.;
Face shield or eye protection in combination with breathing protection.
Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.
•INGESTION Burns in mouth and throat. Burning sensation in the throat and chest. Abdominal cramps. Vomiting. Convulsions. Shock or collapse. (Further see Inhalation). 0
Do not eat, drink, or smoke during work. Wash hands before eating.
Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer immediately for medical attention. m Give plenty of water to drink. at update 2007; about the adequacy of the induction of vomiting !;

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Ventilation. Collect leaking liquid in sealable containers. Absorb remaining liquid in dry sand or inert absorbent and remove to safe place. m Do NOT wash away into sewer. at update 2007 because this does not meet the criteria in CG; neutralize remainder with dilute ammonia (max. 10%).
Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Cool. Dry. Well closed. Ventilation along the floor. Store in an area without drain or sewer access. - deselected by chem. group; 22105000
Unbreakable packaging: put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs.
Note: E
T+ symbol
R: 45-25-26-34-43-68
S: 53-45
UN Hazard Class: 6.1
UN Subsidiary Risks: 8
UN Packing Group: I
Signal: Danger
Corr-Skull-Health haz
Combustible liquid
Fatal if inhaled vapour
Toxic if swallowed
Causes severe skin burns and eye damage
May cause allergic skin reaction
Suspected of causing genetic defects
May cause cancer
Causes damage to liver, kidney, lung
Causes damage to lung through prolonged or repeated exposure
Harmful to aquatic life
ICSC: 0148 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

DIMETHYL SULFATE

ICSC: 0148

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PHYSICAL STATE; APPEARANCE:
COLOURLESS , OILY LIQUID .

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance decomposes on heating or on burning producing toxic fumes including sulfur oxides . The solution in water is a medium strong acid. Reacts with water to produce sulfuric acid with evolution of heat. Reacts violently with concentrated ammonia, bases, acids and strong oxidants, causing fire and explosion hazard. m free phrase of with risk of fire and explosion at update 2007;

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 0.1 ppm as TWA, (skin), A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2008).
MAK: skin absorption (H);
Carcinogen category: 2;
(DFG 2008).
OSHA PEL†: TWA 1 ppm (5 mg/m3) skin
NIOSH REL: Ca TWA 0.1 ppm (0.5 mg/m3) skin See Appendix A
NIOSH IDLH: Ca 7 ppm See: 77781


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

INHALATION RISK:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is corrosive to the eyes, the skin and the respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema (see Notes). The substance may cause effects on the liver and kidneys , resulting in impaired functions . Exposure far above the OEL may result in death. The effects may be delayed. Medical observation is indicated. m Inhalation of the vapour may cause lung oedema (see Notes). at update 2007; eleted Ingestion of the substance may cause oedema of lips, tongue and pharynx. at update 2007 because this is duplicative info of 13718; , P of C; ==> GHS cat 1 (liver, kidney, lung); Peer-review 2008: CNS deletion ok, no animal data

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Lungs may be affected by repeated or prolonged exposure to the vapour. This substance is probably carcinogenic to humans. Repeated or prolonged contact may cause skin sensitization. based on the positive in LNA test, ==> GHS cat 1), Added at update 2007;

PHYSICAL
PROPERTIES

Decomposes at 188 °C
Melting point: -32°C
Relative density (water = 1): 1.3
Solubility in water, g/100 ml at 18°C: 2.8
Vapour pressure, Pa at 20°C: 65
Relative vapour density (air = 1): 4.4
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point:
83°C c.c.
Auto-ignition temperature: 470°C
Explosive limits, vol% in air: 3.6-23.3
Octanol/water partition coefficient as log Pow: 0.16

ENVIRONMENTAL
DATA

The substance is harmful to aquatic organisms.

N O T E S

Commercial dimethyl sulfate may contain trace amounts of sulfuric acid. Depending on the degree of exposure, periodic medical examination is suggested. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered. There is no odour warning even when toxic concentrations are present. Do NOT take working clothes home.
Transport Emergency Card: TEC (R)-61S1595 or 61GTC1-I

NFPA Code: H4, F2, R1.

ADDITIONAL INFORMATION



ICSC: 0148 DIMETHYL SULFATE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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