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NIOSH

MORPHOLINE

ICSC: 0302

Tetrahydro-1,4-oxazine
Diethylene oximide
C4H9NO
Molecular mass: 87.1
ICSC # 0302 		CAS # 110-91-8
RTECS # QD6475000
UN # 2054
EC # 613-028-00-9
November 04, 2000 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Flammable. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames, NO sparks, and NO smoking.
Powder, alcohol-resistant foam, water spray, carbon dioxide.
EXPLOSION Above 35°C explosive vapour/air mixtures may be formed.
Above 35°C use a closed system, ventilation, and explosion-proof electrical equipment.
In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
PREVENT GENERATION OF MISTS! AVOID ALL CONTACT!
IN ALL CASES CONSULT A DOCTOR!
•INHALATION Burning sensation. Cough. Laboured breathing. Shortness of breath. Symptoms may be delayed (see Notes).
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Half-upright position. Artificial respiration if indicated. Refer for medical attention. See Notes.
•SKIN MAY BE ABSORBED! Redness. Pain. Skin burns. Blisters.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
•EYES Redness. Pain. Blurred vision. Severe deep burns.
Face shield or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION Abdominal pain. Burning sensation. Cough. Diarrhoea. Nausea. Shock or collapse. Vomiting.
Do not eat, drink, or smoke during work.
Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. (Extra personal protection: complete protective clothing including self-contained breathing apparatus).
Fireproof. Separated from strong oxidants, acids. Dry.

C symbol
R: 10-20/21/22-34
S: (1/2-)23-36-45
UN Hazard Class: 8
UN Subsidiary Risks: 3
UN Packing Group: I
ICSC: 0302 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

MORPHOLINE

ICSC: 0302

I

M

P

O

R

T

A

N

T


D

A

T

A

PHYSICAL STATE; APPEARANCE:
COLOURLESS HYGROSCOPIC LIQUID , WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance decomposes on burning producing toxic fumes including nitrogen oxides and carbon monoxide . The substance is a medium strong base. Reacts with strong oxidants causing fire hazard. Attacks plastics, rubber and coatings. Unstable if stored in copper or zinc containers.

OCCUPATIONAL EXPOSURE LIMITS:
TLV (as TWA): 20 ppm; mg/m3 (A4 skin) (ACGIH 1999).
EU OEL: 10 ppm, 36 mg/m3 as TWA; 20 ppm, 72 mg/m3 as STEL (EU 2006).
MAK:
Pregnancy risk group: D
(DFG 2006).
OSHA PEL†: TWA 20 ppm (70 mg/m3) skin
NIOSH REL: TWA 20 ppm (70 mg/m3) ST 30 ppm (105 mg/m3) skin
NIOSH IDLH: 1400 ppm 10%LEL See: 110918


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

INHALATION RISK:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is corrosive to the eyes, the skin and the respiratory tract. Corrosive on ingestion. Inhalation of vapour of the substance may cause lung oedema (see Notes).

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
The substance may have effects on the liver and kidneys .

PHYSICAL
PROPERTIES

Boiling point: 129°C
Melting point: -5°C
Relative density (water = 1): 1.0
Solubility in water:
miscible
Vapour pressure, kPa at 20°C: 1.06
Relative vapour density (air = 1): 3.00
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.01
Flash point:
35°C c.c.
Auto-ignition temperature: 310°C
Explosive limits, vol% in air: 1.4-11.2
Octanol/water partition coefficient as log Pow: -0.86

ENVIRONMENTAL
DATA


N O T E S

Depending on the degree of exposure, periodic medical examination is indicated. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate inhalation therapy (e.g. spray), by a doctor or a person authorized by him/her, should be considered. Card has been partly updated in October 2006. See sections Occupational Exposure Limits, Ingestion First Aid.
Transport Emergency Card: TEC (R)-697

NFPA Code: H 2; F 3; R 0;

ADDITIONAL INFORMATION



ICSC: 0302 MORPHOLINE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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