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NIOSH

PHTHALIC ANHYDRIDE

ICSC: 0315

1,2-Benzenedicarboxylic acid anhydride
Phthalic acid anhydride
1,3-Isobenzofurandione
C8H4O3 / C6H4(CO)2O
Molecular mass: 148.1
ICSC # 0315 		CAS # 85-44-9
RTECS # TI3150000
EC # 607-009-00-4
June 05, 2003 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Combustible.
NO open flames.
Water spray, foam, dry powder, carbon dioxide.
EXPLOSION Finely dispersed particles form explosive mixtures in air.
Prevent deposition of dust; closed system, dust explosion-proof electrical equipment and lighting.

EXPOSURE
PREVENT DISPERSION OF DUST! AVOID ALL CONTACT!

•INHALATION Cough. Sore throat. Wheezing.
Local exhaust or breathing protection.
Fresh air, rest. Half-upright position. Refer for medical attention.
•SKIN Redness. Pain.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
•EYES Redness. Pain.
Safety goggles or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION Abdominal pain.
Do not eat, drink, or smoke during work.
Rinse mouth. Do NOT induce vomiting. Give plenty of water to drink. Refer for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Sweep spilled substance into covered containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Personal protection: chemical protection suit including self-contained breathing apparatus.
Separated from combustible and reducing substances, strong oxidants, strong bases, strong acids, , food and feedstuffs . See Chemical Dangers. Ventilation along the floor. Dry. Well closed.
Do not transport with food and feedstuffs.
Xn symbol
R: 22-37/38-41-42/43
S: 2-23-24/25-26-37/39-46
ICSC: 0315 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

PHTHALIC ANHYDRIDE

ICSC: 0315

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PHYSICAL STATE; APPEARANCE:
WHITE LUSTROUS CRYSTALS , WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:
Dust explosion possible if in powder or granular form, mixed with air.

CHEMICAL DANGERS:
The substance decomposes on contact with hot water producing phthalic acid. Reacts with strong oxidants, strong acids, strong bases and reducing agents. Reacts violently on heating with copper oxide or sodium nitrite, causing explosion hazard. Attacks many metals in the presence of water.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 1 ppm; SEN; A4 (not classifiable as a human carcinogen); (ACGIH 2003).
MAK: IIb (not established but data is available); sensitization of respiratory tract (Sa); (DFG 2002).
OSHA PEL†: TWA 12 mg/m3 (2 ppm)
NIOSH REL: TWA 6 mg/m3 (1 ppm)
NIOSH IDLH: 60 mg/m3 See: 85449


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

INHALATION RISK:
A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is severely irritating to the eyes , the skin and the respiratory tract .

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation exposure may cause asthma (see Notes).

PHYSICAL
PROPERTIES

Boiling point: 284°C
(sublimes)
Melting point: 131°C
Density: 1.53
g/cm3
Solubility in water: slow reaction
Vapour pressure, Pa at 20°C: <0.3
Relative vapour density (air = 1): 5.1
Flash point:
152°C c.c.
Auto-ignition temperature: 570°C
Explosive limits, vol% in air: 1.7-10.4
Octanol/water partition coefficient as log Pow: 1.6

ENVIRONMENTAL
DATA


N O T E S

The substance may be transported in molten state. The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance. For materials containing more than 0.05% of maleic anhydride the UN number is 2214, hazard class 8, packaging group III and the Transport Emergency Card is TEC (R)-80S2214. Do NOT take working clothes home. Card has been partly updated in October 2005. See section Occupational Exposure Limits.
NFPA Code: H 3; F 1; R 0

ADDITIONAL INFORMATION



ICSC: 0315 PHTHALIC ANHYDRIDE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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