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NIOSH

para-TOLUIDINE

ICSC: 0343

4-Amino-1-methylbenzene
4-Aminotoluene
p-Methylaniline
C7H9N / C6H4CH3NH2
Molecular mass: 107.2
ICSC # 0343 		CAS # 106-49-0
RTECS # XU3150000
UN # 3451
EC # 612-160-00-4
March 13, 1995 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames. NO contact with nitric acid.
Powder . Foam. Carbon dioxide.
EXPLOSION Above 86°C explosive vapour/air mixtures may be formed.
Above 86°C use a closed system, ventilation.
In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
PREVENT DISPERSION OF DUST! STRICT HYGIENE!
IN ALL CASES CONSULT A DOCTOR!
•INHALATION Blue lips or finger nails. Blue skin. Confusion. Dizziness. Headache. Laboured breathing. Nausea. Shortness of breath. Unconsciousness. Weakness.
Local exhaust or breathing protection.
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
•SKIN MAY BE ABSORBED! Redness. Blue lips or fingernails. Blue skin. (Further see Inhalation).
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
•EYES Redness. Pain. Severe deep burns.
Safety goggles.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION Blue lips or fingernails. Blue skin. Dizziness. Headache. Laboured breathing. (Further see Inhalation).
Do not eat, drink, or smoke during work.
Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Sweep spilled substance into sealable containers. Carefully collect remainder, then remove to safe place. Personal protection: complete protective clothing including self-contained breathing apparatus.
Separated from strong oxidants, strong acids, food and feedstuffs . Cool. Dry. Well closed. Ventilation along the floor.
Do not transport with food and feedstuffs.
T symbol
N symbol
R: 23/24/25-36-40-43-50
S: 1/2-28-36/37-45-61
UN Hazard Class: 6.1
UN Packing Group: II
ICSC: 0343 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

para-TOLUIDINE

ICSC: 0343

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P

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T

A

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D

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A

PHYSICAL STATE; APPEARANCE:
COLOURLESS FLAKES TURNS DARK ON EXPOSURE TO AIR AND LIGHT.

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance decomposes on heating or on burning producing toxic fumes including nitrogen oxides . Reacts violently with oxidants, especially nitric acid.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 2 ppm as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued; (ACGIH 2004).
MAK: skin absorption (H); sensitization of skin (Sh);
Carcinogen category: 3B;
(DFG 2007).
OSHA PEL†: none
NIOSH REL: Ca See Appendix A
NIOSH IDLH: Ca N.D. See: IDLH INDEX


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation and through the skin and by ingestion.

INHALATION RISK:
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying or when dispersed, especially if powdered.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance irritates the eyes and the skin. The substance may cause effects on the blood , bladder and kidneys , resulting in tissue lesions and formation of methaemoglobin. Exposure to high concentrations may result in damage to kidneys and bladder. The effects may be delayed. Medical observation is indicated. See Notes.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the blood , resulting in formation of methaemoglobin (see Notes).

PHYSICAL
PROPERTIES

Boiling point: 200°C
Melting point: 44-45°C
Relative density (water = 1): 1.05
Solubility in water:
poor
Vapour pressure, kPa at 42°C: 0.13
Relative vapour density (air = 1): 3.9
Flash point: 86-87°C c.c.
Auto-ignition temperature: 482°C
Explosive limits, vol% in air: 1.1-6.6
Octanol/water partition coefficient as log Pow: 1.39

ENVIRONMENTAL
DATA


N O T E S

Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. The odour warning when the exposure limit value is exceeded is insufficient. Do NOT take working clothes home. Also consult ICSC # 0341 ortho-Toluidine and 0342 meta-Toluidine. Card has been partly updated in October 2005. See sections Occupational Exposure Limits, EU classification, Emergency Response.
Transport Emergency Card: TEC (R)-61GT2-II

NFPA Code: H3; F2; R0
Card has been partially updated in January 2008: see Fire fighting.

ADDITIONAL INFORMATION



ICSC: 0343 para-TOLUIDINE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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