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NIOSH

METHIDATHION

ICSC: 1659

O,O-Dimethyl S-(2,3-dihydro-5-methoxy-2-oxo-1,3,4-thiadiazol-3-ylmethyl) phosphorodithioate
O,O-Dimethyl-S-(5-methoxy-1,3,4-thiadiazolinyl-3-methyl) dithiophosphate
C6H11N2O4PS3
Molecular mass: 302.3
ICSC # 1659 		CAS # 950-37-8
RTECS # TE2100000
UN # 2783
EC # 015-069-00-2
October 11, 2006 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
water spray. Dry powder. Carbon dioxide.
EXPLOSION


EXPOSURE
PREVENT DISPERSION OF DUST!
IN ALL CASES CONSULT A DOCTOR!
•INHALATION Dizziness. Nausea. Sweating. Muscle twitching. Pupillary constriction, muscle cramp, excessive salivation. Laboured breathing. Convulsions. Unconsciousness.
Local exhaust or breathing protection.
Fresh air, rest. Artificial respiration may be needed. Refer immediately for medical attention.
•SKIN MAY BE ABSORBED! (see Inhalation).
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention. Wear protective gloves when administering first aid.
•EYES Blurred vision.
Face shield or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION Abdominal cramps. Diarrhoea. Vomiting. (Further see Inhalation).
Do not eat, drink, or smoke during work. Wash hands before eating.
Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. Carefully collect remainder, then remove to safe place.
Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Well closed. Store in an area without drain or sewer access.
Do not transport with food and feedstuffs.
Marine pollutant.
T+ symbol
N symbol
R: 21-28-50/53
S: 1/2-22-28-36/37-45-60-61
UN Hazard Class: 6.1
UN Packing Group: II
Signal: Danger
Skull-Health haz-Enviro
Fatal if swallowed
Fatal in contact with skin
Fatal if inhaled
Causes damage to nervous system
Very toxic to aquatic life
ICSC: 1659 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

METHIDATHION

ICSC: 1659

I

M

P

O

R

T

A

N

T


D

A

T

A

PHYSICAL STATE; APPEARANCE:
COLOURLESS CRYSTALS

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance decomposes on heating producing toxic fumes.

OCCUPATIONAL EXPOSURE LIMITS:
TLV not established.
MAK not established.


ROUTES OF EXPOSURE:
The substance can be absorbed into the body in hazardous amounts by inhalation, through the skin and by ingestion.

INHALATION RISK:
A harmful concentration of airborne particles can be reached quickly when dispersed.

EFFECTS OF SHORT-TERM EXPOSURE:
Cholinesterase inhibition. The substance may cause effects on the nervous system , resulting in convulsions and respiratory depression . Exposure may result in death. The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Cholinesterase inhibitor; cumulative effect is possible: see acute hazards/symptoms.

PHYSICAL
PROPERTIES

Melting point: 39°C
Density: 1.5
g/cm3
Solubility in water, g/100 ml at 20°C: 0.0187
Vapour pressure, kPa at 20°C: negligible
Flash point: 100°C
Octanol/water partition coefficient as log Pow: 2.2

ENVIRONMENTAL
DATA

The substance is very toxic to aquatic organisms. This substance does enter the environment under normal use. Great care, however, should be given to avoid any additional release, e.g. through inappropriate disposal.

N O T E S

Carrier solvents used in commercial formulations may change physical and toxicological properties. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Do NOT take working clothes home.
Transport Emergency Card: TEC (R)-(61GT7-II)
Card has been partially updated in January 2008: see GHS classification.

ADDITIONAL INFORMATION



ICSC: 1659 METHIDATHION
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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