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Volume 5:
No. 3, July 2008
ORIGINAL RESEARCH
National Trends and Disparities in the Incidence of Hepatocellular
Carcinoma, 1998–2003
Men, by Race
| Age, y |
Rate per 100,000 |
| All races |
White |
Black |
Asian/Pacific Islander |
| 20-24 |
0.1 |
0.1 |
0.2 |
0.4 |
| 25-29 |
0.2 |
0.1 |
0.4 |
1.1 |
| 30-34 |
0.3 |
0.2 |
0.7 |
2.1 |
| 35-39 |
0.8 |
0.4 |
1.5 |
5.3 |
| 40-44 |
2.3 |
1.8 |
3.8 |
8.5 |
| 45-49 |
7.5 |
6.1 |
14.0 |
18.9 |
| 50-54 |
11.0 |
8.9 |
23.0 |
27.1 |
| 55-59 |
12.3 |
10.0 |
23.5 |
37.2 |
| 60-64 |
15.1 |
12.5 |
22.6 |
56.0 |
| 65-69 |
20.6 |
18.0 |
26.1 |
71.1 |
| 70-74 |
24.1 |
21.6 |
31.8 |
75.2 |
| 75-79 |
27.0 |
25.2 |
27.6 |
80.0 |
| 80-84 |
23.2 |
21.7 |
24.7 |
70.6 |
| ≥85 |
17.9 |
16.6 |
19.7 |
57.9 |
Women, by Race
| Age, y |
Rate per 100,000 |
| All races |
White |
Black |
Asian/Pacific Islander |
| 20-24 |
0.1 |
0.1 |
0.1 |
0.4 |
| 25-29 |
0.1 |
0.1 |
0.1 |
0.1 |
| 30-34 |
0.1 |
0.1 |
0.2 |
0.5 |
| 35-39 |
0.2 |
0.2 |
0.5 |
0.6 |
| 40-44 |
0.5 |
0.3 |
1.0 |
1.6 |
| 45-49 |
1.2 |
1.0 |
2.0 |
2.4 |
| 50-54 |
1.7 |
1.4 |
2.9 |
4.6 |
| 55-59 |
2.6 |
2.1 |
4.4 |
7.3 |
| 60-64 |
4.2 |
3.4 |
5.9 |
18.2 |
| 65-69 |
6.5 |
5.2 |
8.2 |
30.1 |
| 70-74 |
8.1 |
7.0 |
10.9 |
33.2 |
| 75-79 |
8.8 |
7.8 |
11.6 |
30.7 |
| 80-84 |
8.6 |
7.8 |
10.3 |
34.5 |
| ≥85 |
6.1 |
5.9 |
5.5 |
19.8 |
Men and Women, by Ethnicity
| Age, y |
Rate per 100,000 |
| Hispanic men |
Non-Hispanic men |
Hispanic women |
Non-Hispanic women |
| 20-24 |
0.1 |
0.1 |
0 |
0.1 |
| 25-29 |
0.1 |
0.2 |
0.1 |
0.1 |
| 30-34 |
0.3 |
0.4 |
0.1 |
0.2 |
| 35-39 |
0.7 |
0.8 |
0.2 |
0.2 |
| 40-44 |
3.5 |
2.2 |
0.4 |
0.5 |
| 45-49 |
13.8 |
6.8 |
1.7 |
1.1 |
| 50-54 |
19.6 |
10.2 |
2.7 |
1.7 |
| 55-59 |
27.1 |
11.1 |
5.9 |
2.3 |
| 60-64 |
31.5 |
13.9 |
9.7 |
3.8 |
| 65-69 |
46.3 |
18.7 |
15.8 |
5.8 |
| 70-74 |
49.6 |
22.5 |
19.8 |
7.4 |
| 75-79 |
60.6 |
25.2 |
26.6 |
7.8 |
| 80-84 |
44.7 |
22.3 |
24.0 |
8.0 |
| ≥85 |
40.7 |
16.8 |
22.5 |
5.5 |
Figure 1. Age-Specific Incidence of Hepatocellular
Carcinoma, by Patients’ Sex and Race/Ethnicity, United States, 1998–2003.
Data cover 83% of the U.S. population and are from population-based cancer registries that participate in the National Program of Cancer Registries (NPCR) and the Surveillance, Epidemiology, and End Results (SEER) Program and that met study criteria.
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| Characteristic |
APC |
| Male |
Female |
| Race/Ethnicity |
| White |
4.8a |
4.5a |
| Black |
6.0a |
1.7 |
| Asian/Pacific Islander |
0.4 |
1.2 |
| Hispanic |
3.6a |
1.8 |
| Age, y |
| <45 |
-0.6 |
-1.6 |
| 45-59 |
9.0a |
9.0a |
| 60-74 |
3.6a |
3.2a |
| ≥75 |
2.6a |
3.8a |
| Region |
| Midwest |
3.6a |
2.9 |
| South |
5.9a |
5.2a |
| Northeast |
6.2a |
5.9a |
| West |
3.3a |
3.0 |
| Race/Ethnicity (Among Those Aged
45-59 y) |
| White |
10.4a |
9.5a |
| Black |
8.9a |
12.3a |
| Asian/Pacific Islander |
-2.7 |
-0.3 |
| Hispanic |
8.8a |
3.5 |
Figure 2. Annual Percentage Change (APC) in Incidence
of Hepatocellular Carcinoma, United States, 1998–2003.
Data cover 83% of the U.S. population and are from population-based cancer registries that participate in the National Program of Cancer Registries (NPCR) and the Surveillance, Epidemiology, and End Results (SEER) Program and that met study criteria.
a P < .05 indicates that the APC is significantly greater than zero.
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