Acanthosis nigricans

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Background

  • Multiple forms, but malignant acanthosis nigricans is most important
  • Clinically indistinguishable from benign form

Clinical Features

  • Hyperpigmented, velvety
  • Plaques
  • Most commonly intertriginous areas, posterior neck
  • May have concurrent acrochordons, skin tags

Malignant Acanthosis Nigricans[1]

  • Associated with other dermal manifestations of internal cancers
  • Most commonly associated with colonic adenocarcinoma, gastric cancer
  • Red flags:
    • Up to 50% of malignant acanthosis nigricans have oral involvement
    • Rapid appearance of lesions
Acanthosis-nigricans associatd with gastric Ca.jpg

See Also

References

  1. Miller JH et al. Acanthosis Nigricans Clinical Presentation. eMedicine. Dec 3, 2015. http://emedicine.medscape.com/article/1102488-clinical#showall.