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Carvedilol
From WikEM
Contents
Administration
- Type: Beta-blocker
- Dosage Forms:
- Routes of Administration: oral
- Common Trade Names: Coreg
Adult Dosing
- 3.125-50mg BID
Pediatric Dosing
Safety/efficacy not established
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: no adjustment
- Hepatic dosing: contraindicated in severe liver disease
Contraindications
- Allergy to class/drug
- Cardiogenic shock
- Asthma or other bronchospastic condition
- 2nd or 3rd degree AV block, severe bradycardia, sick sinus
- Severe hepatic impairment
Adverse Reactions
Serious
- AV block, bradyarrhythmia, hypotension
- SJS/TEN
- Aplastic anemia
- Asthma with status asthmaticus
- Intraoperative floppy iris syndrome (?!)
Common
- Bradyarrhythmia, hypotension
- Peripheral edema
- Weight gain, hyperglycemia
- Diarrhea
- Dizziness, fatigue
- Erectile dysfunction
Pharmacology
- Half-life: 7-10h
- Metabolism: Hepatic CYP2D6
- Excretion: Fecal/biliary
Mechanism of Action
- Nonselective beta-blocker with alpha-1 blocking activity
