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Cortisone
From WikEM
Contents
Administration
- Type: Corticosteroid
- Dosage Forms:
- Routes of Administration: oral, IV/IM
- Common Trade Names:
Adult Dosing
- 25-300mg PO daily
Pediatric Dosing
- 0.5-0.75 mg/kg/day OR 20-25 mg/m(2)/day PO in 3 doses
- 0.25-0.35 mg/kg/day OR 12.5 mg/m(2)/day IM
Special Populations
- Pregnancy Rating: D
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: no adjustment
- Hepatic dosing: no adjustment
Contraindications
- Allergy to class/drug
- Systemic fungal infections (except when used for replacement therapy in adrenal insufficiency)
- Concomitant administration of live or live attenuated vaccines
Adverse Reactions
Serious
- Adrenocortical insufficiency
- Hyperglycemia
- Cataract, glaucoma
- Osteoporosis
Common
- Hypertension
- Increased infection risk, poor wound healing
- Skin atrophy
- Cushing syndrome
- Growth impairment
- Depression, euphoria
Pharmacology
- Half-life:
- Metabolism: Hepatic
- Excretion: Renal
Mechanism of Action
- Synthetic glucocorticoid
