Dapsone

Administration

• Type: Antibiotic
• Dosage Forms: 25,100
• Routes of Administration: Oral

Adult Dosing

• Hansen disease (leprosy)
  • paucibacillary: 100mg PO qd x6mo
    • Use with rifampin
  • multibacillary: 100mg PO qd x12mo
    • Use with rifampin, clofazimine

• Dermatitis herpetiformis: 50mg PO qd

• PCP prophylaxis: 100mg/day PO divided qd-bid
  • Off label use

• PCP treatment: 100mg PO qd x21 days
  • Not 1st-line agent; use with trimethoprim
  • Off label use

• Malaria suppression: 100mg PO qwk
  • Use with pyrimethamine
  • Off label use

• Toxoplasmosis prophylaxis: 50mg PO qd
  • Off label use

Special Populations

• Pregnancy Rating: C
• Lactation risk: Probably unsafe

Renal Dosing

• No adjustment

Hepatic Dosing

• Caution advised with hepatic impairment
• CBC qwk x4, qmo x6, then q6mo thereafter
• LFTs at baseline, then periodically

Contraindications

• Allergy to class/drug
• caution if renal or hepatic impairment
• caution if impaired cardiovascular function

Adverse Reactions

Serious

• anemia, hemolytic
• aplastic anemia
• agranulocytosis
• exfoliative dermatitis
• erythema multiforme
• toxic epidermal necrolysis

Common

• fever
• myalgia
• headache
• rigors
• fatigue
• malaise
• dizziness

Pharmacology

• Half-life: 28 hrs
• Metabolism: Liver, CYP450
• Excretion: Urine

References

Authors

Kristina Shigyo, Amr Badawy, Daniel Ostermayer, Neil Young, Claire