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Deferoxamine
From WikEM
Contents
General
- Type:
- Dosage Forms:
- Routes of Administration:
- Common Trade Names:
Adult Dosing
Iron toxicity
- 1000mg IV; start at 5mg/kg/hr, increase up to 15mg/kg/hr as tolerated for up to 24hrs
- Subsequent doses are 500mg increments guided by clinical status of patient / urine color
- Recommended amount during first 24hr is 360mg/kg not to exceed 6g.
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation risk:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Indications
- Systemic toxicity and iron level > 350 mcg/dL
- Metabolic acidosis
- Progressive symptoms
- Serum iron level >500 mcg/dL
Contraindications
- Allergy to class/drug
- Renal failure patients not on hemodialysis
Adverse Reactions
- Hypotension (pre-existing hypotension is NOT a contraindication to therapy)
- ARDS
- Yersinia enterocolitica sepsis[1]
- Can see "vin rose" colored urine from chelated iron extretion
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Comments
- Chelates iron and creates a water-soluble compound ferrioxamine that is renally excreted and can be dialyzed.[2]
See Also
References
- ↑ Mazzoleni G. et al. Yersinia enterocolitica infection with ileal perforation associated with iron overload and deferoxamine therapy. Dig Dis Sci 1991; 36:1154-1160.
- ↑ Cite error: Invalid
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