We need you! Join our contributor community and become a WikEM editor through our open and transparent promotion process.
Droperidol
From WikEM
Contents
Administration
- Type: antipsychotic, antiemetics
- Dosage Forms:
- Routes of Administration: IV/IM
- Common Trade Names:
Adult Dosing
Combative patient
- 10mg IM
Headache
- 2.5mg IV or 2.5-5mg IM
Nausea/vomiting
- 0.625-2.5mg IV
Pediatric Dosing
Nausea/vomiting
- 2-12yo: 0.015-0.1mg/kg IV/IM
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: Administer with caution
- Hepatic dosing: Administer with caution
Contraindications
- Allergy to class/drug
- Known or suspected prolonged QT
Adverse Reactions
Serious
- Prolonged QT, torsades, ventricular tachycardia, cardiac arrest
- Note: effect on QT interval is dose-dependent
- Neuroleptic malignant syndrome
- Anaphylaxis
Common
- Somnolence, dysphoria
- Anxiety, restlessness, hyperactivity
- Hypotension
- Tachycardia
Pharmacology
- Half-life: 123-147m (adults), 75-127m (children)
- Metabolism: hepatic
- Excretion: mostly renal
Mechanism of Action
- Dopamine (D2) antagonist. Some serotonergic, histaminergic, and alpha-adrenergic effect
