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Famciclovir
From WikEM
Contents
General
- Type: DNA polymerase inhibitor
- Dosage Forms: 125, 250, 500 PO
- Common Trade Names: Famvir
Adult Dosing
HSV-1
- 500mg PO TID
Pediatric Dosing
- Unavailable
Special Populations
- Pregnancy Rating: B
- Lactation: Safety Unknown
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
- Famvir Pregnancy Registry: 1-888-669-6682
Contraindications
- Allergy to class/drug
- caution if renal impairment
Adverse Reactions
Serious
- neutropenia
- thrombocytopenia
- skin reaction, severe
- hallucinations
- delirium
Common
- headache
- nausea
- diarrhea
- vomiting
- fatigue
- pruritus
- neutropenia
- abnormal LFTs
- paresthesia
- flatulence
Pharmacology
- Half-life: 2-3h
- Metabolism: liver, CYP450
- Excretion: urine primarily, feces
- Mechanism of Action: inhibits DNA polymerase, selectively inhibiting herpes viral DNA synthesis and replication
