Fenoldopam

Administration

• Type: Antihypertensive, Dopamine agonist
• Dosage Forms: 10mg/mL (1 mL), 20mg/2 mL (2 mL)
• Routes of Administration: Intravenous
• Common Trade Names: Corlopam

Adult Dosing

• Severe hypertension: Initial 0.01 to 0.3 msg/kg/minute, increase incrementally 0.05 to 0.1 msg/kg/minute q 15 minute until target blood pressure is reached (maximum dose recorded in the study was 1.6 mcg/kg/minute), limit for up to 48-hour use.

Pediatric Dosing

• Severe hypertension: Initial 0.2 mcg/kg/minute; increase incrementally 0.3 to 0.5 mcg/kg/minute q 20 to 30 minutes (maximum 0.8 mcg/kg/minute), limit for 4-hour use

Special Populations

• Pregnancy Rating: B
• Lactation risk: Not defined

Renal Dosing

• Adult: Not defined
• Pediatric: Not defined

Hepatic Dosing

• Adult: Not defined
• Pediatric: Not defined

Contraindications

• Allergy to class/drug
• Caution if:
  • sulfite hypersensitivity
  • asthma
  • glaucoma, intraocular HTN, elevated ICP
  • acute stroke
  • cardiac disease, arrythmias
  • hypokalemia
  • active bleeding
  • portal hypertension

Adverse Reactions

Serious

• hypotension, severe
• tachycardia
• CHF, MI, angina
• hypokalemia
• leukocytosis

Common

• headache, dizziness
• flushing, diaphoresis, anxiety, tachycardia
• hypotension
• ST-T wave changes
• nausea/vomiting, abdominal pain, diarrhea, constipation
• injection site reaction
• back pain
• nasal congestion
• IOP elevation

Pharmacology

• Half-life: 5 min
• Metabolism: Liver extensively; CYP450
• Excretion: urine 90%, feces 10%

Mechanism of Action

• stimulates dopamine D1-like and alpha-2 adrenergic receptors

See Also

• Hypertension

References

Authors

Yajai Apibunyopas, Kaoru Itakura, Claire, Ross Donaldson, Neil Young