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Fluticasone propionate
From WikEM
Contents
Administration
- Type: Corticosteroid
- Dosage Forms:
- Routes of Administration: Inhalation, intranasal, topical
- Common Trade Names: Flonase
Adult Dosing
- Intranasal: 2 sprays/nostril daily
- Aerosol: 88-880 mcg BID
- Powder (inhaled): 100-1000 mcg BID
- Topical application: 1-2 times daily
Pediatric Dosing
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: no adjustment
- Hepatic dosing: no adjustment
Contraindications
- Allergy to class/drug
- Severe hypersensitivity to milk proteins
- Primary treatment of acute asthma exacerbation
Adverse Reactions
Serious
- Secondary hypocortisolism
- Glaucoma, elevated ICP
- Pneumonia
Common
- Oral or esophageal candidiasis
- Nausea/vomiting
- Headache
- Osteoporosis
- Cough, URI symptoms
- Epistaxis
Pharmacology
- Half-life: 3.2-11.2h
- Metabolism: Hepatic CYP3A4
- Excretion: Fecal
Mechanism of Action
- Glucocorticoid, anti-inflammatory
