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Foscarnet
From WikEM
Contents
Administration
- Type: Antiviral
- Dosage Forms:
- Routes of Administration: IV
- Common Trade Names: Foscavir
Adult Dosing
- CMV retinitis: 90 mg/kg IV q12h OR 60 mg/kg IV q8h for 2-3 weeks, then maintenance 90-120 mg/kg IV daily
- HSV resistant to acyclovir, immunocompromised: 40 mg/kg IV 2-3 times daily
- VZV resistant to acyclovir, HIV+: 90 mg/kg IV q12h
Pediatric Dosing
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: Complicated dose adjustment required!
- Hepatic dosing: No adjustement
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Hyperphosphatemia, hypophosphatemia, hypocalcemia, hypokalemia, hypomagnesemia
- Pancreatitis
- Pancytopenia
- Renal failure, renal impairment
- Seizure
Common
- Nausea, vomiting, diarrhea
- Anemia, granulocytopenic disorder
- Headache
- Fever
Pharmacology
- Half-life: 3.3-4h
- Metabolism:
- Excretion: Renal
Mechanism of Action
- inhibits pyrophosphate binding on viral DNA polymerases
