Iodoquinol

Administration

• Type: Amebicide
• Routes of Administration: Oral
• Common Trade Names: Aloquin; Yodoxin

Adult Dosing

• 650mg 3 times daily after meals for 20 days
  • Not to exceed 1.95 g daily

Pediatric Dosing

• Children: 30-40mg/kg daily (maximum: 650mg per dose) in 3 divided doses for 20 days
  • Not to exceed 1.95 g daily

Special Populations

• Limited data on use during pregnancy

Renal Dosing

• No adjustments noted by manufacturer

Hepatic Dosing

• No adjustments noted by manufacturer

Contraindications

• Allergy to class/drug, hypersensitivity to iodine and/or 8-hydroxyquinolones
• Concerns with optic neuritis
• Concerns with peripheral neuropathy
• Hepatic impairment
• Renal impairment
• Chronic diarrhea, especially in children

Adverse Reactions

Serious

• Peripheral neuropathy, Long-term (high-dose)
• Optic atrophy, Long-term (high-dose)
• Optic neuritis, Long-term (high-dose)

Common

• Nausea/vomiting, diarrhea, cramps
• Fever/chills
• Pruritus, urticaria
• Headache, dizziness

Pharmacology

• Half-life:
• Metabolism: Liver
• Excretion: Feces, urine

Mechanism of Action

• Contact amebicide that works in the lumen of the intestine (unknown mechanism)

See Also

• Parasitic diseases

References

<UpToDate>

Authors

Kristina Shigyo, Claire, Daniel Ostermayer, Neil Young