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Lisinopril
From WikEM
Contents
General
- Type: ACE inhibitor
- Dosage Forms: 2.5, 5, 10, 20, 30, 40
- Common Trade Names: Prinivil, Zestril
General information:
- Doses > 40mg/day rarely more effective
- Decreased efficacy as mono therapy in Black patients
- Obtain Chem 10 if starting in ED to assess renal function
Adult Dosing
- hypertension: 10 - 40mg PO Qday, max 80mg/day
Pediatric Dosing
- 6-16 year old: 0.07mg/kg PO qday, max 40mg/day
Special Populations
- Pregnancy Rating: D
- Lactation: Safety unknown
- Renal Dosing
- Adult: CrCl < 30, start 2.5mg qday, max 40mg q/day
- Pediatric creatinine Cl 30-50: decrease dose 50%, CrCl < 30, avoid use
- Hepatic Dosing
- Adult: Not defined
- Pediatric: Not defined
Contraindications
- Allergy to class/drug
- history of angioedema
- pregnancy
- caution if renal artery stenosis
- caution if severe CHF
- caution if renal impairment
Adverse Reactions
Serious
- angioedema
- hypotension
- hyperkalemia
- renal impairment
- hepatotoxicity
- neutropenia
- pancreatitis
- steven johnson syndrome
- fetal/neonatal harm
- congenital malformations
Common
- dizziness
- elevated Cr
- headache
- diarrhea
- hypotension
- abdominal pain
- hyperkalemia
Pharmacology
- Half-life: 12 hours
- Metabolism: none
- Excretion: urine
- Mechanism of Action: inhibits angiotensin converting enzyme, interferes with conversion of angiotensin 1 to angiotensin 2
See Also
References
Authors
Babak Missaghi, Ross Donaldson, Neil Young, Claire, Daniel Ostermayer
