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Mebendazole
From WikEM
Contents
Administration
- Type: Antiparasitic (used to treat nematodes)
- Dosage Forms:
- Routes of Administration: Oral
- Common Trade Names:
Adult Dosing
- 100mg PO BID x 3 days
Pediatric Dosing
≥2yo: 100mg PO BID x 3 days
Special Populations
- Pregnancy Rating: C
- Lactation risk: infant risk cannot be ruled out
- Renal dosing: no adjustment
- Hepatic impairment: may need dose reduction
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Agranulocytosis
- Hepatitis
- Seizure
- Angioedema
Common
- Abdominal pain, diarrhea
Pharmacology
- Half-life: 0.8-11.5h
- Metabolism: Hepatic
- Excretion: Fecal
Mechanism of Action
- Causes parasitic microtubules to degenerate, inhibiting glucose uptake and glycogen storage
