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Mupirocin
From WikEM
Contents
General
- Type: Antibacterials, Topical
- Dosage Forms: 2% cream, ointment
- Routes of Administration: topical
- Common Trade Names: Bactroban, Centany
Adult Dosing
Impetigo
- apply ointment TID x 7-14 days
Skin infections, bacterial
- apply cream TID x 10 days
Pediatric Dosing
Impetigo (2mos and older)
- apply ointment TID x 7-14 days
Skin infections, bacterial (3mos and older)
- apply cream TID x 10 days
Special Populations
- Pregnancy Rating: B
- Lactation risk: probably safe
Renal Dosing
- Adult: NA
- Pediatric: NA
Hepatic Dosing
- Adult: NA
- Pediatric: NA
Contraindications
- Allergy to class/drug
- large open wounds
- caution if renal impairment, mod-severe
Adverse Reactions
Serious
- hypersensitivity run
- anaphylaxis
- C. difficile-assoc diarrhea
- superinfection (prolonged use)
Common
- nausea
- burning
- headache
- pruritus
- pain
- stinging
Pharmacology
- Half-life: 20-40 min
- Metabolism: liver; CYP450; <0.3% systemic absorption
- Excretion: urine <3%
- Mechanism of Action: bacteriostatic or bactericidal, depending on susceptibility and concentration; reversibly binds to isoleucyl-tRNA synthetase, inhibiting protein synthesis (monoxycarbolic acid)
