We need you! Join our contributor community and become a WikEM editor through our open and transparent promotion process.
Naloxone
From WikEM
Contents
General
- Type: Opioid antagonists
- Dosage Forms:
- Common Trade Names: Narcan
Adult Dosing
Opioid toxicity
- Bolus (May repeat q3min up to max dose 10mg
- Apneic or near-apneic - 2mg IV
- Opioid-naive with minimal respiratory depression - 0.4mg IV
- Opioid-dependent with minimal respiratory depression - 0.05mg IV
- Infusion
- Only give if the patient responded to the bolus and required repeat administration
- Step 1: Determine the "wake-up dose" or bolus required to wake the pt
- Step 2: Give 2/3 of the "wake-up dose" per hr; mix in 1L D5W
Pediatric Dosing
- IV: 0.005 to 0.01mg/kg IV every 2 to 3 minutes as needed to desired degree of reversal
- If IV route is not available, may administer in divided doses IM
Special Populations
- Pregnancy Rating: C
- Lactation: insufficient data
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
- Opioid withdrawal
- Serious complications are rare
Pharmacology
- Metabolism: hepatic
- Excretion: renal
- Mechanism of Action: opioid antagonist
- Onset of action - 1-2min
- Duration of action - 20-90min (may be less than that of the ingested opioid)
