Neomycin

Administration

• Type: Aminoglycoside; bowel preps
• Dosage Forms: 500
• Routes of Administration: PO
• Common Trade Names: Neo-Fradin

Adult Dosing

Bowel Prep

• 1000mg PO at 1 pm, 2 pm and 11 pm the day before 8 am surgery. Alternative: 1000mg po q1h x 4, then 1000mg po q4h x 4

Hepatic Encephalopathy

• 1000-3000mg po q6h x 5-6 days

Pediatric Dosing

Bowel prep for 2-12 y/o

• 25mg/kg PO at 1 pm, 2 pm and 11 pm the day before 8 am surgery. Alternative: 90mg/kg/day PO divided q4h x 2-3 days

Special Populations

• Pregnancy Rating:D
• Lactation risk: safety unknown

Renal Dosing

• Adult: not defined
• Pediatric:not defined

Hepatic Dosing

• Adult:not defined
• Pediatric:not defined

Contraindications

• Allergy to class/drug
• GI obstruction

Adverse Reactions

Serious

• nephrotoxicity
• ototoxicity
• neurotoxicity
• superinfection

Common

• nausea
• vomiting
• diarrhea

Pharmacology

• Half-life: 2-3 hour
• Metabolism: none
• Excretion: feces

Mechanism of Action

Bactericidal and amebicidal; binds to bacterial 30s ribosomal subunit, inhibiting protein synthesis, suppresses urease producing bacteria; reducing ammonia absorption from gut

References

Authors

Babak Missaghi, Neil Young, Daniel Ostermayer